297188

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 4227639..4228681 Replicon chromosome
Accession NZ_OX638701
Organism Pseudomonas aeruginosa strain 4782MK isolate 4782MK

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag QSK41_RS19960 Protein ID WP_003153636.1
Coordinates 4228106..4228681 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag QSK41_RS19955 Protein ID WP_003050245.1
Coordinates 4227639..4228109 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSK41_RS19920 (PAER4782_19925) 4223031..4224449 - 1419 WP_006226029.1 TIGR03752 family integrating conjugative element protein -
QSK41_RS19925 (PAER4782_19930) 4224439..4225350 - 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
QSK41_RS19930 (PAER4782_19935) 4225347..4226039 - 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
QSK41_RS19935 (PAER4782_19940) 4226036..4226434 - 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
QSK41_RS19940 (PAER4782_19945) 4226446..4226805 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
QSK41_RS19945 (PAER4782_19950) 4226822..4227055 - 234 WP_003090170.1 TIGR03758 family integrating conjugative element protein -
QSK41_RS19950 (PAER4782_19955) 4227052..4227435 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
QSK41_RS19955 (PAER4782_19960) 4227639..4228109 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
QSK41_RS19960 (PAER4782_19965) 4228106..4228681 + 576 WP_003153636.1 PIN domain-containing protein Toxin
QSK41_RS19965 (PAER4782_19970) 4228678..4229613 + 936 WP_033970552.1 AAA family ATPase -
QSK41_RS19970 (PAER4782_19975) 4229610..4230080 + 471 WP_003090160.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
QSK41_RS19975 (PAER4782_19980) 4230077..4230577 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
QSK41_RS19980 (PAER4782_19985) 4230577..4231479 + 903 WP_003090158.1 CBASS oligonucleotide cyclase -
QSK41_RS19985 (PAER4782_19990) 4231518..4232243 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4152831..4274797 121966


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T297188 WP_003153636.1 NZ_OX638701:4228106-4228681 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT297188 WP_003050245.1 NZ_OX638701:4227639-4228109 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References