Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 3283662..3285170 Replicon chromosome
Accession NZ_OX638701
Organism Pseudomonas aeruginosa strain 4782MK isolate 4782MK

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag QSK41_RS15310 Protein ID WP_079276297.1
Coordinates 3283662..3284249 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag QSK41_RS15315 Protein ID WP_003119683.1
Coordinates 3284316..3285170 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSK41_RS15305 (PAER4782_15305) 3279917..3283396 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
QSK41_RS15310 (PAER4782_15310) 3283662..3284249 + 588 WP_079276297.1 GNAT family protein Toxin
QSK41_RS15315 (PAER4782_15315) 3284316..3285170 + 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
QSK41_RS15320 (PAER4782_15320) 3285267..3287432 + 2166 WP_003115567.1 TonB-dependent receptor family protein -
QSK41_RS15325 (PAER4782_15325) 3287607..3289481 + 1875 WP_003117607.1 MFS transporter -
QSK41_RS15330 (PAER4782_15335) 3289542..3289751 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21892.22 Da        Isoelectric Point: 9.8675

>T297187 WP_079276297.1 NZ_OX638701:3283662-3284249 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQQGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT297187 WP_003119683.1 NZ_OX638701:3284316-3285170 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References