Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3024230..3025925 Replicon chromosome
Accession NZ_OX638701
Organism Pseudomonas aeruginosa strain 4782MK isolate 4782MK

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag QSK41_RS14075 Protein ID WP_048910032.1
Coordinates 3024230..3025099 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag QSK41_RS14080 Protein ID WP_003112902.1
Coordinates 3025092..3025925 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSK41_RS14050 (PAER4782_14060) 3020238..3021089 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
QSK41_RS14055 (PAER4782_14065) 3021130..3022137 + 1008 WP_003162724.1 ABC transporter substrate-binding protein -
QSK41_RS14060 (PAER4782_14070) 3022134..3022910 + 777 WP_003112898.1 ABC transporter permease -
QSK41_RS14065 (PAER4782_14075) 3022916..3023677 + 762 WP_079274766.1 SDR family oxidoreductase -
QSK41_RS14070 (PAER4782_14080) 3023691..3024221 + 531 WP_003162721.1 cupin domain-containing protein -
QSK41_RS14075 (PAER4782_14085) 3024230..3025099 + 870 WP_048910032.1 alpha/beta hydrolase Toxin
QSK41_RS14080 (PAER4782_14090) 3025092..3025925 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
QSK41_RS14085 (PAER4782_14095) 3025912..3026709 + 798 WP_003112903.1 SDR family oxidoreductase -
QSK41_RS14090 (PAER4782_14100) 3026702..3028384 + 1683 WP_003112904.1 thiamine pyrophosphate-binding protein -
QSK41_RS14095 (PAER4782_14105) 3028395..3029198 + 804 WP_003112905.1 aspartate dehydrogenase -
QSK41_RS14100 (PAER4782_14110) 3029210..3030694 + 1485 WP_033970726.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30336.60 Da        Isoelectric Point: 6.5894

>T297186 WP_048910032.1 NZ_OX638701:3024230-3025099 [Pseudomonas aeruginosa]
MNMAQTHIPAPSLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSPIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT297186 WP_003112902.1 NZ_OX638701:3025092-3025925 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References