Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1428557..1429062 Replicon chromosome
Accession NZ_OX638701
Organism Pseudomonas aeruginosa strain 4782MK isolate 4782MK

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag QSK41_RS06580 Protein ID WP_003083773.1
Coordinates 1428557..1428838 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag QSK41_RS06585 Protein ID WP_003083775.1
Coordinates 1428835..1429062 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSK41_RS06555 (PAER4782_06535) 1423808..1425157 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
QSK41_RS06560 (PAER4782_06540) 1425206..1425892 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
QSK41_RS06565 (PAER4782_06545) 1425993..1426727 + 735 WP_003117208.1 GntR family transcriptional regulator -
QSK41_RS06570 (PAER4782_06550) 1426907..1427317 + 411 WP_003110659.1 aegerolysin family protein -
QSK41_RS06575 (PAER4782_06555) 1427349..1428257 - 909 WP_003083769.1 LysR family transcriptional regulator -
QSK41_RS06580 (PAER4782_06560) 1428557..1428838 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
QSK41_RS06585 (PAER4782_06565) 1428835..1429062 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
QSK41_RS06590 (PAER4782_06570) 1429237..1429857 - 621 WP_003101226.1 hypothetical protein -
QSK41_RS06595 (PAER4782_06575) 1429958..1430458 + 501 WP_003162763.1 LEA type 2 family protein -
QSK41_RS06600 (PAER4782_06580) 1430531..1430872 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
QSK41_RS06605 (PAER4782_06585) 1430954..1432381 - 1428 WP_003083784.1 GABA permease -
QSK41_RS06610 (PAER4782_06590) 1432550..1434043 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T297185 WP_003083773.1 NZ_OX638701:c1428838-1428557 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT297185 WP_003083775.1 NZ_OX638701:c1429062-1428835 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References