Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2829310..2830568 Replicon chromosome
Accession NZ_OX638610
Organism Pseudomonas aeruginosa strain 3541 isolate 3541

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag QPK16_RS13170 Protein ID WP_003086331.1
Coordinates 2829813..2830568 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag QPK16_RS13165 Protein ID WP_003086329.1
Coordinates 2829310..2829678 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPK16_RS13145 (JCHGIK_14460) 2825473..2825748 + 276 WP_023088486.1 zinc ribbon domain-containing protein -
QPK16_RS13150 (JCHGIK_14465) 2825751..2826227 - 477 WP_009877993.1 elongation factor GreAB -
QPK16_RS13155 (JCHGIK_14470) 2826402..2827895 + 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
QPK16_RS13160 (JCHGIK_14475) 2827951..2829237 + 1287 WP_003134035.1 FAD-binding oxidoreductase -
QPK16_RS13165 (JCHGIK_14480) 2829310..2829678 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
QPK16_RS13170 (JCHGIK_14485) 2829813..2830568 + 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
QPK16_RS13175 (JCHGIK_14495) 2831341..2832702 + 1362 WP_003134034.1 DNA recombination protein RmuC -
QPK16_RS13180 (JCHGIK_14500) 2832857..2835400 - 2544 WP_043543407.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T297179 WP_003086331.1 NZ_OX638610:2829813-2830568 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT297179 WP_003086329.1 NZ_OX638610:2829310-2829678 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References