Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 2274278..2274886 Replicon chromosome
Accession NZ_OX638610
Organism Pseudomonas aeruginosa strain 3541 isolate 3541

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag QPK16_RS10465 Protein ID WP_003114156.1
Coordinates 2274539..2274886 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag QPK16_RS10460 Protein ID WP_003114155.1
Coordinates 2274278..2274529 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPK16_RS10440 (JCHGIK_11800) 2269925..2270281 + 357 WP_003114150.1 DUF2523 family protein -
QPK16_RS10445 (JCHGIK_11805) 2270285..2271559 + 1275 WP_043096062.1 zonular occludens toxin family protein -
QPK16_RS10450 (JCHGIK_11815) 2271789..2273081 + 1293 WP_003115206.1 hypothetical protein -
QPK16_RS10455 (JCHGIK_11820) 2273081..2274064 + 984 WP_003114154.1 tyrosine-type recombinase/integrase -
QPK16_RS10460 2274278..2274529 + 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QPK16_RS10465 (JCHGIK_11825) 2274539..2274886 + 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QPK16_RS10470 2275174..2275815 - 642 WP_003158902.1 substrate-binding domain-containing protein -
QPK16_RS10475 2275937..2276242 + 306 WP_003158903.1 helix-turn-helix transcriptional regulator -
QPK16_RS10480 (JCHGIK_11830) 2276341..2278689 - 2349 WP_176031468.1 S8 family peptidase -
QPK16_RS10485 (JCHGIK_11835) 2278829..2279860 - 1032 WP_003158906.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element sul1 / blaIMP-13 - 2261229..2363644 102415


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T297178 WP_003114156.1 NZ_OX638610:2274539-2274886 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT297178 WP_003114155.1 NZ_OX638610:2274278-2274529 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References