Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 554592..555097 Replicon chromosome
Accession NZ_OX638610
Organism Pseudomonas aeruginosa strain 3541 isolate 3541

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag QPK16_RS02640 Protein ID WP_003121619.1
Coordinates 554816..555097 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag QPK16_RS02635 Protein ID WP_003112628.1
Coordinates 554592..554819 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPK16_RS02610 (JCHGIK_03965) 549610..551103 + 1494 WP_043095997.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
QPK16_RS02615 (JCHGIK_03970) 551272..552699 + 1428 WP_003083784.1 GABA permease -
QPK16_RS02620 (JCHGIK_03975) 552781..553122 - 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
QPK16_RS02625 (JCHGIK_03980) 553195..553695 - 501 WP_003101228.1 LEA type 2 family protein -
QPK16_RS02630 (JCHGIK_03985) 553796..554416 + 621 WP_003101226.1 hypothetical protein -
QPK16_RS02635 (JCHGIK_03990) 554592..554819 + 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
QPK16_RS02640 (JCHGIK_03995) 554816..555097 + 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
QPK16_RS02645 (JCHGIK_04000) 555397..556305 + 909 WP_016561475.1 LysR family transcriptional regulator -
QPK16_RS02650 (JCHGIK_04005) 556337..556747 - 411 WP_003101225.1 aegerolysin family protein -
QPK16_RS02655 (JCHGIK_04010) 556927..557661 - 735 WP_043095998.1 GntR family transcriptional regulator -
QPK16_RS02660 (JCHGIK_04015) 557762..558448 - 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
QPK16_RS02665 (JCHGIK_04020) 558497..559846 - 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T297176 WP_003121619.1 NZ_OX638610:554816-555097 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT297176 WP_003112628.1 NZ_OX638610:554592-554819 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References