297173

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5436037..5436645 Replicon chromosome
Accession NZ_OX638564
Organism Pseudomonas aeruginosa strain 3796A isolate 3796A

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag QRQ54_RS25405 Protein ID WP_003114156.1
Coordinates 5436037..5436384 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag QRQ54_RS25410 Protein ID WP_003114155.1
Coordinates 5436394..5436645 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRQ54_RS25385 (PAE3796A_25225) 5431063..5432094 + 1032 WP_003158906.1 AAA family ATPase -
QRQ54_RS25390 (PAE3796A_25230) 5432234..5434582 + 2349 WP_176031468.1 S8 family peptidase -
QRQ54_RS25395 5434681..5434986 - 306 WP_003158903.1 helix-turn-helix transcriptional regulator -
QRQ54_RS25400 5435108..5435749 + 642 WP_003158902.1 substrate-binding domain-containing protein -
QRQ54_RS25405 (PAE3796A_25235) 5436037..5436384 - 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QRQ54_RS25410 5436394..5436645 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QRQ54_RS25415 (PAE3796A_25240) 5436859..5437842 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
QRQ54_RS25420 (PAE3796A_25245) 5437842..5439134 - 1293 WP_003115206.1 hypothetical protein -
QRQ54_RS25425 (PAE3796A_25255) 5439364..5440638 - 1275 WP_043096062.1 zonular occludens toxin family protein -
QRQ54_RS25430 (PAE3796A_25260) 5440642..5440998 - 357 WP_003114150.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element blaIMP-13 / sul1 - 5290779..5449694 158915


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T297173 WP_003114156.1 NZ_OX638564:c5436384-5436037 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT297173 WP_003114155.1 NZ_OX638564:c5436645-5436394 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References