Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4898776..4900034 Replicon chromosome
Accession NZ_OX638564
Organism Pseudomonas aeruginosa strain 3796A isolate 3796A

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag QRQ54_RS22895 Protein ID WP_003086331.1
Coordinates 4898776..4899531 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag QRQ54_RS22900 Protein ID WP_003086329.1
Coordinates 4899666..4900034 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRQ54_RS22885 (PAE3796A_22725) 4893944..4896487 + 2544 WP_043543407.1 acyl-homoserine-lactone acylase QuiP -
QRQ54_RS22890 (PAE3796A_22730) 4896642..4898003 - 1362 WP_003134034.1 DNA recombination protein RmuC -
QRQ54_RS22895 (PAE3796A_22740) 4898776..4899531 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
QRQ54_RS22900 (PAE3796A_22745) 4899666..4900034 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
QRQ54_RS22905 (PAE3796A_22750) 4900107..4901393 - 1287 WP_003134035.1 FAD-binding oxidoreductase -
QRQ54_RS22910 (PAE3796A_22755) 4901449..4902942 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
QRQ54_RS22915 (PAE3796A_22760) 4903117..4903593 + 477 WP_009877993.1 elongation factor GreAB -
QRQ54_RS22920 (PAE3796A_22765) 4903596..4903871 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T297172 WP_003086331.1 NZ_OX638564:c4899531-4898776 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT297172 WP_003086329.1 NZ_OX638564:c4900034-4899666 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References