Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3900129..3901350 Replicon chromosome
Accession NZ_OX638564
Organism Pseudomonas aeruginosa strain 3796A isolate 3796A

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag QRQ54_RS18025 Protein ID WP_003102740.1
Coordinates 3900772..3901350 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QRQ54_RS18020 Protein ID WP_003088112.1
Coordinates 3900129..3900683 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRQ54_RS17995 (PAE3796A_17860) 3895697..3896248 + 552 WP_003102727.1 XRE family transcriptional regulator -
QRQ54_RS18000 (PAE3796A_17865) 3896245..3896643 - 399 WP_023089053.1 NADH-quinone oxidoreductase subunit A -
QRQ54_RS18005 (PAE3796A_17870) 3896656..3896979 - 324 WP_003102734.1 multidrug efflux SMR transporter -
QRQ54_RS18010 (PAE3796A_17875) 3897310..3897771 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
QRQ54_RS18015 (PAE3796A_17880) 3897776..3899971 + 2196 WP_043096806.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
QRQ54_RS18020 (PAE3796A_17885) 3900129..3900683 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
QRQ54_RS18025 (PAE3796A_17890) 3900772..3901350 + 579 WP_003102740.1 HD domain-containing protein Toxin
QRQ54_RS18030 (PAE3796A_17895) 3901459..3902646 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
QRQ54_RS18035 (PAE3796A_17900) 3902636..3904807 - 2172 WP_033983956.1 type I secretion system permease/ATPase -
QRQ54_RS18040 (PAE3796A_17905) 3904797..3906074 - 1278 WP_003122808.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T297171 WP_003102740.1 NZ_OX638564:3900772-3901350 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT297171 WP_003088112.1 NZ_OX638564:3900129-3900683 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References