Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 3900129..3901350 | Replicon | chromosome |
Accession | NZ_OX638564 | ||
Organism | Pseudomonas aeruginosa strain 3796A isolate 3796A |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A0C7CS07 |
Locus tag | QRQ54_RS18025 | Protein ID | WP_003102740.1 |
Coordinates | 3900772..3901350 (+) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | QRQ54_RS18020 | Protein ID | WP_003088112.1 |
Coordinates | 3900129..3900683 (+) | Length | 185 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QRQ54_RS17995 (PAE3796A_17860) | 3895697..3896248 | + | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
QRQ54_RS18000 (PAE3796A_17865) | 3896245..3896643 | - | 399 | WP_023089053.1 | NADH-quinone oxidoreductase subunit A | - |
QRQ54_RS18005 (PAE3796A_17870) | 3896656..3896979 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
QRQ54_RS18010 (PAE3796A_17875) | 3897310..3897771 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
QRQ54_RS18015 (PAE3796A_17880) | 3897776..3899971 | + | 2196 | WP_043096806.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
QRQ54_RS18020 (PAE3796A_17885) | 3900129..3900683 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
QRQ54_RS18025 (PAE3796A_17890) | 3900772..3901350 | + | 579 | WP_003102740.1 | HD domain-containing protein | Toxin |
QRQ54_RS18030 (PAE3796A_17895) | 3901459..3902646 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
QRQ54_RS18035 (PAE3796A_17900) | 3902636..3904807 | - | 2172 | WP_033983956.1 | type I secretion system permease/ATPase | - |
QRQ54_RS18040 (PAE3796A_17905) | 3904797..3906074 | - | 1278 | WP_003122808.1 | TolC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21869.70 Da Isoelectric Point: 5.3655
>T297171 WP_003102740.1 NZ_OX638564:3900772-3901350 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT297171 WP_003088112.1 NZ_OX638564:3900129-3900683 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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