Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1909849..1911357 Replicon chromosome
Accession NZ_OX638564
Organism Pseudomonas aeruginosa strain 3796A isolate 3796A

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag QRQ54_RS08825 Protein ID WP_003119682.1
Coordinates 1909849..1910436 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag QRQ54_RS08830 Protein ID WP_003091607.1
Coordinates 1910503..1911357 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRQ54_RS08820 (PAE3796A_08815) 1906104..1909583 - 3480 WP_003091610.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
QRQ54_RS08825 (PAE3796A_08820) 1909849..1910436 + 588 WP_003119682.1 GNAT family protein Toxin
QRQ54_RS08830 (PAE3796A_08825) 1910503..1911357 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
QRQ54_RS08835 (PAE3796A_08830) 1911454..1913619 + 2166 WP_043096211.1 TonB-dependent receptor family protein -
QRQ54_RS08840 (PAE3796A_08835) 1913794..1915668 + 1875 WP_010793244.1 MFS transporter -
QRQ54_RS08845 (PAE3796A_08845) 1915729..1915938 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T297170 WP_003119682.1 NZ_OX638564:1909849-1910436 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT297170 WP_003091607.1 NZ_OX638564:1910503-1911357 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References