297169

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 154281..154786 Replicon chromosome
Accession NZ_OX638564
Organism Pseudomonas aeruginosa strain 3796A isolate 3796A

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag QRQ54_RS00705 Protein ID WP_003121619.1
Coordinates 154281..154562 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag QRQ54_RS00710 Protein ID WP_003112628.1
Coordinates 154559..154786 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRQ54_RS00680 (PAE3796A_00640) 149532..150881 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
QRQ54_RS00685 (PAE3796A_00645) 150930..151616 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
QRQ54_RS00690 (PAE3796A_00650) 151717..152451 + 735 WP_043095998.1 GntR family transcriptional regulator -
QRQ54_RS00695 (PAE3796A_00655) 152631..153041 + 411 WP_003101225.1 aegerolysin family protein -
QRQ54_RS00700 (PAE3796A_00660) 153073..153981 - 909 WP_016561475.1 LysR family transcriptional regulator -
QRQ54_RS00705 (PAE3796A_00665) 154281..154562 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
QRQ54_RS00710 (PAE3796A_00670) 154559..154786 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
QRQ54_RS00715 (PAE3796A_00675) 154962..155582 - 621 WP_003101226.1 hypothetical protein -
QRQ54_RS00720 (PAE3796A_00680) 155683..156183 + 501 WP_003101228.1 LEA type 2 family protein -
QRQ54_RS00725 (PAE3796A_00685) 156256..156597 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
QRQ54_RS00730 (PAE3796A_00690) 156679..158106 - 1428 WP_003083784.1 GABA permease -
QRQ54_RS00735 (PAE3796A_00695) 158275..159768 - 1494 WP_043095997.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T297169 WP_003121619.1 NZ_OX638564:c154562-154281 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT297169 WP_003112628.1 NZ_OX638564:c154786-154559 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References