Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4258007..4258583 Replicon chromosome
Accession NZ_OX637964
Organism Escherichia coli O25b:H4-ST131 isolate 46

Toxin (Protein)


Gene name shpA Uniprot ID A0A061KXE4
Locus tag QQG90_RS21200 Protein ID WP_001295743.1
Coordinates 4258296..4258583 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A066STF6
Locus tag QQG90_RS21195 Protein ID WP_000063148.1
Coordinates 4258007..4258309 (-) Length 101 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQG90_RS21180 (4254603) 4254603..4256753 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QQG90_RS21185 (4256803) 4256803..4257006 + 204 WP_000467859.1 YbdD/YjiX family protein -
QQG90_RS21190 (4257017) 4257017..4257973 + 957 WP_001295745.1 GTPase -
QQG90_RS21195 (4258007) 4258007..4258309 - 303 WP_000063148.1 BrnA antitoxin family protein Antitoxin
QQG90_RS21200 (4258296) 4258296..4258583 - 288 WP_001295743.1 BrnT family toxin Toxin
QQG90_RS21205 (4258780) 4258780..4259946 + 1167 WP_000800831.1 restriction endonuclease -
QQG90_RS21210 (4260010) 4260010..4261629 + 1620 WP_001029745.1 class I SAM-dependent DNA methyltransferase -
QQG90_RS21215 (4261619) 4261619..4262923 + 1305 WP_000535012.1 restriction endonuclease subunit S -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11156.62 Da        Isoelectric Point: 7.4697

>T297155 WP_001295743.1 NZ_OX637964:c4258583-4258296 [Escherichia coli O25b:H4-ST131]
MPMEFEWDANKAKSNRVKHGIRFEDAVLVFDDPQHLSQQDRIENGEYRWQTIGLVHGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERSRYEHG

Download         Length: 288 bp


Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11592.12 Da        Isoelectric Point: 9.4646

>AT297155 WP_000063148.1 NZ_OX637964:c4258309-4258007 [Escherichia coli O25b:H4-ST131]
MSMVKHKRGTPSTLDVQHEAELKALANKFDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A061KXE4


Antitoxin

Source ID Structure
AlphaFold DB A0A066STF6

References