Detailed information of TA system TA297153

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3880416..3882105
• Replicon: chromosome
• Accession: NZ_OX637964
• Organism: Escherichia coli O25b:H4-ST131 isolate 46

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QQG90_RS19380
• Protein ID: WP_000365807.1
• Coordinates: 3880416..3881336 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QQG90_RS19385
• Protein ID: WP_001295795.1
• Coordinates: 3881323..3882105 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QQG90_RS19340 (3875889)	3875889..3876599	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QQG90_RS19345 (3876906)	3876906..3877235	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QQG90_RS19350 (3877247)	3877247..3877413	-	167	Protein_3794	tail fiber assembly protein	-
QQG90_RS19355 (3877484)	3877484..3878098	-	615	WP_001019923.1	YagU family protein	-
QQG90_RS19360 (3878313)	3878313..3878498	-	186	WP_000146240.1	hypothetical protein	-
QQG90_RS19365 (3878547)	3878547..3878705	+	159	Protein_3797	integrase	-
QQG90_RS19370 (3878932)	3878932..3879267	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QQG90_RS19375 (3879475)	3879475..3880251	+	777	WP_000171155.1	site-specific integrase	-
QQG90_RS19380 (3880416)	3880416..3881336	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QQG90_RS19385 (3881323)	3881323..3882105	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QQG90_RS19390 (3882389)	3882389..3885487	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3840200..3889168	48968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T297153 WP_000365807.1 NZ_OX637964:c3881336-3880416 [Escherichia coli O25b:H4-ST131]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT297153 WP_001295795.1 NZ_OX637964:c3882105-3881323 [Escherichia coli O25b:H4-ST131]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0