Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3696334..3696952 Replicon chromosome
Accession NZ_OX637964
Organism Escherichia coli O25b:H4-ST131 isolate 46

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QQG90_RS18515 Protein ID WP_001291435.1
Coordinates 3696734..3696952 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QQG90_RS18510 Protein ID WP_000344800.1
Coordinates 3696334..3696708 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQG90_RS18500 (3691423) 3691423..3692616 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QQG90_RS18505 (3692639) 3692639..3695788 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QQG90_RS18510 (3696334) 3696334..3696708 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QQG90_RS18515 (3696734) 3696734..3696952 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QQG90_RS18520 (3697126) 3697126..3697677 + 552 WP_000102539.1 maltose O-acetyltransferase -
QQG90_RS18525 (3697793) 3697793..3698263 + 471 WP_000136192.1 YlaC family protein -
QQG90_RS18530 (3698427) 3698427..3699977 + 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QQG90_RS18535 (3700019) 3700019..3700372 - 354 WP_000878135.1 DUF1428 family protein -
QQG90_RS18545 (3700751) 3700751..3701062 + 312 WP_000409908.1 MGMT family protein -
QQG90_RS18550 (3701093) 3701093..3701665 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T297152 WP_001291435.1 NZ_OX637964:3696734-3696952 [Escherichia coli O25b:H4-ST131]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT297152 WP_000344800.1 NZ_OX637964:3696334-3696708 [Escherichia coli O25b:H4-ST131]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References