Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870069..870723 Replicon chromosome
Accession NZ_OX637964
Organism Escherichia coli O25b:H4-ST131 isolate 46

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QQG90_RS04315 Protein ID WP_000244765.1
Coordinates 870316..870723 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QQG90_RS04310 Protein ID WP_000354050.1
Coordinates 870069..870335 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQG90_RS04290 (866157) 866157..867590 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
QQG90_RS04295 (867635) 867635..867946 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QQG90_RS04300 (868110) 868110..868769 + 660 WP_000250275.1 hemolysin III family protein -
QQG90_RS04305 (868846) 868846..869826 - 981 WP_000886084.1 tRNA-modifying protein YgfZ -
QQG90_RS04310 (870069) 870069..870335 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QQG90_RS04315 (870316) 870316..870723 + 408 WP_000244765.1 protein YgfX Toxin
QQG90_RS04320 (870763) 870763..871284 - 522 WP_001055874.1 flavodoxin FldB -
QQG90_RS04325 (871396) 871396..872292 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QQG90_RS04330 (872317) 872317..873027 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QQG90_RS04335 (873033) 873033..874766 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T297143 WP_000244765.1 NZ_OX637964:870316-870723 [Escherichia coli O25b:H4-ST131]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT297143 WP_000354050.1 NZ_OX637964:870069-870335 [Escherichia coli O25b:H4-ST131]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References