Detailed information of TA system TA297125

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3759704..3761393
• Replicon: chromosome
• Accession: NZ_OX637961
• Organism: Escherichia coli O25b:H4-ST131 isolate 86

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QQG89_RS18385
• Protein ID: WP_000365807.1
• Coordinates: 3759704..3760624 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QQG89_RS18390
• Protein ID: WP_001295795.1
• Coordinates: 3760611..3761393 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QQG89_RS18345 (3755177)	3755177..3755887	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QQG89_RS18350 (3756194)	3756194..3756523	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QQG89_RS18355 (3756535)	3756535..3756701	-	167	Protein_3601	tail fiber assembly protein	-
QQG89_RS18360 (3756772)	3756772..3757386	-	615	WP_001019923.1	YagU family protein	-
QQG89_RS18365 (3757601)	3757601..3757786	-	186	WP_000146240.1	hypothetical protein	-
QQG89_RS18370 (3757835)	3757835..3757993	+	159	Protein_3604	integrase	-
QQG89_RS18375 (3758220)	3758220..3758555	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QQG89_RS18380 (3758763)	3758763..3759539	+	777	WP_000171155.1	site-specific integrase	-
QQG89_RS18385 (3759704)	3759704..3760624	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QQG89_RS18390 (3760611)	3760611..3761393	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QQG89_RS18395 (3761677)	3761677..3764775	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3719771..3768456	48685

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T297125 WP_000365807.1 NZ_OX637961:c3760624-3759704 [Escherichia coli O25b:H4-ST131]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT297125 WP_001295795.1 NZ_OX637961:c3761393-3760611 [Escherichia coli O25b:H4-ST131]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0