Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2852663..2853134 Replicon chromosome
Accession NZ_OX637961
Organism Escherichia coli O25b:H4-ST131 isolate 86

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QQG89_RS14005 Protein ID WP_001303511.1
Coordinates 2852856..2853134 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QQG89_RS14000 Protein ID WP_001302048.1
Coordinates 2852663..2852854 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQG89_RS13955 (2847912) 2847912..2848130 - 219 WP_001610644.1 DUF4014 family protein -
QQG89_RS13960 (2848163) 2848163..2848375 - 213 WP_000072553.1 hypothetical protein -
QQG89_RS13965 (2848481) 2848481..2848903 - 423 Protein_2742 DUF977 family protein -
QQG89_RS13970 (2848919) 2848919..2849689 - 771 WP_000450998.1 DUF1627 domain-containing protein -
QQG89_RS13975 (2849711) 2849711..2850457 - 747 WP_000788950.1 ATP-binding protein -
QQG89_RS13980 (2850464) 2850464..2851426 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QQG89_RS13985 (2851449) 2851449..2851874 - 426 WP_000693943.1 toxin YdaT family protein -
QQG89_RS13990 (2851871) 2851871..2852173 - 303 WP_001556930.1 transcriptional regulator -
QQG89_RS13995 (2852271) 2852271..2852642 + 372 WP_001169687.1 hypothetical protein -
QQG89_RS14000 (2852663) 2852663..2852854 + 192 WP_001302048.1 hypothetical protein Antitoxin
QQG89_RS14005 (2852856) 2852856..2853134 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QQG89_RS14010 (2853425) 2853425..2853577 + 153 WP_000380313.1 DUF1391 family protein -
QQG89_RS14015 (2853589) 2853589..2853927 + 339 WP_000394541.1 hypothetical protein -
QQG89_RS14020 (2853916) 2853916..2854110 - 195 WP_001295058.1 hypothetical protein -
QQG89_RS14025 (2854686) 2854686..2854874 + 189 WP_000449175.1 cell division inhibition protein DicB -
QQG89_RS14030 (2854871) 2854871..2855059 + 189 WP_000199475.1 DUF1482 family protein -
QQG89_RS14035 (2855152) 2855152..2857590 + 2439 WP_000102132.1 exonuclease -
QQG89_RS14040 (2857652) 2857652..2857921 + 270 WP_000003742.1 excisionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2835273..2862315 27042


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T297121 WP_001303511.1 NZ_OX637961:2852856-2853134 [Escherichia coli O25b:H4-ST131]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT297121 WP_001302048.1 NZ_OX637961:2852663-2852854 [Escherichia coli O25b:H4-ST131]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References