Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 965160..965814 Replicon chromosome
Accession NZ_OX637961
Organism Escherichia coli O25b:H4-ST131 isolate 86

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QQG89_RS04760 Protein ID WP_000244765.1
Coordinates 965407..965814 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QQG89_RS04755 Protein ID WP_000354050.1
Coordinates 965160..965426 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQG89_RS04735 (961248) 961248..962681 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
QQG89_RS04740 (962726) 962726..963037 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QQG89_RS04745 (963201) 963201..963860 + 660 WP_000250275.1 hemolysin III family protein -
QQG89_RS04750 (963937) 963937..964917 - 981 WP_000886080.1 tRNA-modifying protein YgfZ -
QQG89_RS04755 (965160) 965160..965426 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QQG89_RS04760 (965407) 965407..965814 + 408 WP_000244765.1 protein YgfX Toxin
QQG89_RS04765 (965854) 965854..966375 - 522 WP_001055874.1 flavodoxin FldB -
QQG89_RS04770 (966487) 966487..967383 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QQG89_RS04775 (967408) 967408..968118 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QQG89_RS04780 (968124) 968124..969857 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T297113 WP_000244765.1 NZ_OX637961:965407-965814 [Escherichia coli O25b:H4-ST131]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT297113 WP_000354050.1 NZ_OX637961:965160-965426 [Escherichia coli O25b:H4-ST131]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References