Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 3993117..3993667 | Replicon | chromosome |
Accession | NZ_OX637959 | ||
Organism | Escherichia coli O25b:H4-ST131 isolate 32 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | S1PDG4 |
Locus tag | QQG88_RS19485 | Protein ID | WP_001160966.1 |
Coordinates | 3993117..3993431 (-) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | V0VEX8 |
Locus tag | QQG88_RS19490 | Protein ID | WP_000125566.1 |
Coordinates | 3993434..3993667 (-) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QQG88_RS19460 (3988792) | 3988792..3990078 | + | 1287 | WP_000800457.1 | peptidylprolyl isomerase SurA | - |
QQG88_RS19465 (3990078) | 3990078..3991067 | + | 990 | WP_000241227.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
QQG88_RS19470 (3991064) | 3991064..3991885 | + | 822 | WP_001065363.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
QQG88_RS19475 (3991888) | 3991888..3992265 | + | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
QQG88_RS19480 (3992272) | 3992272..3993120 | + | 849 | WP_000257181.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
QQG88_RS19485 (3993117) | 3993117..3993431 | - | 315 | WP_001160966.1 | CcdB family protein | Toxin |
QQG88_RS19490 (3993434) | 3993434..3993667 | - | 234 | WP_000125566.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
QQG88_RS19495 (3993753) | 3993753..3994232 | - | 480 | WP_000624375.1 | type 3 dihydrofolate reductase | - |
QQG88_RS19500 (3994424) | 3994424..3996286 | - | 1863 | WP_000377124.1 | glutathione-regulated potassium-efflux system protein KefC | - |
QQG88_RS19505 (3996279) | 3996279..3996809 | - | 531 | WP_000600725.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
QQG88_RS19510 (3996917) | 3996917..3998248 | - | 1332 | WP_001183207.1 | MFS transporter | - |
QQG88_RS19515 (3998307) | 3998307..3998594 | - | 288 | WP_000203741.1 | ferredoxin-like protein FixX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11711.72 Da Isoelectric Point: 9.0851
>T297099 WP_001160966.1 NZ_OX637959:c3993431-3993117 [Escherichia coli O25b:H4-ST131]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
Download Length: 315 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829G815 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LTM9 |