Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
Location | 3763583..3765272 | Replicon | chromosome |
Accession | NZ_OX637959 | ||
Organism | Escherichia coli O25b:H4-ST131 isolate 32 |
Toxin (Protein)
Gene name | mosT | Uniprot ID | A0A061KTE0 |
Locus tag | QQG88_RS18410 | Protein ID | WP_000365807.1 |
Coordinates | 3763583..3764503 (-) | Length | 307 a.a. |
Antitoxin (Protein)
Gene name | mosA | Uniprot ID | - |
Locus tag | QQG88_RS18415 | Protein ID | WP_001295795.1 |
Coordinates | 3764490..3765272 (-) | Length | 261 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QQG88_RS18370 (3759056) | 3759056..3759766 | + | 711 | WP_001295798.1 | fimbrial chaperone EcpE | - |
QQG88_RS18375 (3760073) | 3760073..3760402 | + | 330 | WP_001295797.1 | YkgJ family cysteine cluster protein | - |
QQG88_RS18380 (3760414) | 3760414..3760580 | - | 167 | Protein_3606 | tail fiber assembly protein | - |
QQG88_RS18385 (3760651) | 3760651..3761265 | - | 615 | WP_001019923.1 | YagU family protein | - |
QQG88_RS18390 (3761480) | 3761480..3761665 | - | 186 | WP_000146240.1 | hypothetical protein | - |
QQG88_RS18395 (3761714) | 3761714..3761872 | + | 159 | Protein_3609 | integrase | - |
QQG88_RS18400 (3762099) | 3762099..3762434 | + | 336 | WP_000996167.1 | Arm DNA-binding domain-containing protein | - |
QQG88_RS18405 (3762642) | 3762642..3763418 | + | 777 | WP_000171155.1 | site-specific integrase | - |
QQG88_RS18410 (3763583) | 3763583..3764503 | - | 921 | WP_000365807.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
QQG88_RS18415 (3764490) | 3764490..3765272 | - | 783 | WP_001295795.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
QQG88_RS18420 (3765556) | 3765556..3768654 | + | 3099 | WP_000673070.1 | type I restriction endonuclease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE | 3723639..3772335 | 48696 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 307 a.a. Molecular weight: 34570.89 Da Isoelectric Point: 7.3239
>T297098 WP_000365807.1 NZ_OX637959:c3764503-3763583 [Escherichia coli O25b:H4-ST131]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE
Download Length: 921 bp
Antitoxin
Download Length: 261 a.a. Molecular weight: 29099.24 Da Isoelectric Point: 8.5975
>AT297098 WP_001295795.1 NZ_OX637959:c3765272-3764490 [Escherichia coli O25b:H4-ST131]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA
Download Length: 783 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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