297098

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3763583..3765272 Replicon chromosome
Accession NZ_OX637959
Organism Escherichia coli O25b:H4-ST131 isolate 32

Toxin (Protein)


Gene name mosT Uniprot ID A0A061KTE0
Locus tag QQG88_RS18410 Protein ID WP_000365807.1
Coordinates 3763583..3764503 (-) Length 307 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag QQG88_RS18415 Protein ID WP_001295795.1
Coordinates 3764490..3765272 (-) Length 261 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQG88_RS18370 (3759056) 3759056..3759766 + 711 WP_001295798.1 fimbrial chaperone EcpE -
QQG88_RS18375 (3760073) 3760073..3760402 + 330 WP_001295797.1 YkgJ family cysteine cluster protein -
QQG88_RS18380 (3760414) 3760414..3760580 - 167 Protein_3606 tail fiber assembly protein -
QQG88_RS18385 (3760651) 3760651..3761265 - 615 WP_001019923.1 YagU family protein -
QQG88_RS18390 (3761480) 3761480..3761665 - 186 WP_000146240.1 hypothetical protein -
QQG88_RS18395 (3761714) 3761714..3761872 + 159 Protein_3609 integrase -
QQG88_RS18400 (3762099) 3762099..3762434 + 336 WP_000996167.1 Arm DNA-binding domain-containing protein -
QQG88_RS18405 (3762642) 3762642..3763418 + 777 WP_000171155.1 site-specific integrase -
QQG88_RS18410 (3763583) 3763583..3764503 - 921 WP_000365807.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QQG88_RS18415 (3764490) 3764490..3765272 - 783 WP_001295795.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
QQG88_RS18420 (3765556) 3765556..3768654 + 3099 WP_000673070.1 type I restriction endonuclease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE 3723639..3772335 48696


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 307 a.a.        Molecular weight: 34570.89 Da        Isoelectric Point: 7.3239

>T297098 WP_000365807.1 NZ_OX637959:c3764503-3763583 [Escherichia coli O25b:H4-ST131]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Download         Length: 921 bp


Antitoxin


Download         Length: 261 a.a.        Molecular weight: 29099.24 Da        Isoelectric Point: 8.5975

>AT297098 WP_001295795.1 NZ_OX637959:c3765272-3764490 [Escherichia coli O25b:H4-ST131]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Download         Length: 783 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A061KTE0


Antitoxin

Source ID Structure

References