Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3600671..3601289 Replicon chromosome
Accession NZ_OX637959
Organism Escherichia coli O25b:H4-ST131 isolate 32

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QQG88_RS17630 Protein ID WP_001291435.1
Coordinates 3601071..3601289 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QQG88_RS17625 Protein ID WP_000344800.1
Coordinates 3600671..3601045 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQG88_RS17615 (3595760) 3595760..3596953 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QQG88_RS17620 (3596976) 3596976..3600125 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QQG88_RS17625 (3600671) 3600671..3601045 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QQG88_RS17630 (3601071) 3601071..3601289 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QQG88_RS17635 (3601462) 3601462..3602013 + 552 WP_000102539.1 maltose O-acetyltransferase -
QQG88_RS17640 (3602129) 3602129..3602599 + 471 WP_000136192.1 YlaC family protein -
QQG88_RS17645 (3602763) 3602763..3604313 + 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QQG88_RS17650 (3604355) 3604355..3604708 - 354 WP_000878147.1 DUF1428 family protein -
QQG88_RS17660 (3605087) 3605087..3605398 + 312 WP_000409908.1 MGMT family protein -
QQG88_RS17665 (3605429) 3605429..3606001 - 573 WP_000779841.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T297097 WP_001291435.1 NZ_OX637959:3601071-3601289 [Escherichia coli O25b:H4-ST131]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT297097 WP_000344800.1 NZ_OX637959:3600671-3601045 [Escherichia coli O25b:H4-ST131]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References