297094

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2852641..2853112 Replicon chromosome
Accession NZ_OX637959
Organism Escherichia coli O25b:H4-ST131 isolate 32

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QQG88_RS14005 Protein ID WP_001303511.1
Coordinates 2852834..2853112 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QQG88_RS14000 Protein ID WP_001302048.1
Coordinates 2852641..2852832 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQG88_RS13955 (2847890) 2847890..2848108 - 219 WP_001610644.1 DUF4014 family protein -
QQG88_RS13960 (2848141) 2848141..2848353 - 213 WP_000072553.1 hypothetical protein -
QQG88_RS13965 (2848459) 2848459..2848881 - 423 Protein_2742 DUF977 family protein -
QQG88_RS13970 (2848897) 2848897..2849667 - 771 WP_000450998.1 DUF1627 domain-containing protein -
QQG88_RS13975 (2849689) 2849689..2850435 - 747 WP_000788950.1 ATP-binding protein -
QQG88_RS13980 (2850442) 2850442..2851404 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QQG88_RS13985 (2851427) 2851427..2851852 - 426 WP_000693943.1 toxin YdaT family protein -
QQG88_RS13990 (2851849) 2851849..2852151 - 303 WP_001556930.1 transcriptional regulator -
QQG88_RS13995 (2852249) 2852249..2852620 + 372 WP_001169687.1 hypothetical protein -
QQG88_RS14000 (2852641) 2852641..2852832 + 192 WP_001302048.1 hypothetical protein Antitoxin
QQG88_RS14005 (2852834) 2852834..2853112 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QQG88_RS14010 (2853403) 2853403..2853555 + 153 WP_000380313.1 DUF1391 family protein -
QQG88_RS14015 (2853567) 2853567..2853905 + 339 WP_000394541.1 hypothetical protein -
QQG88_RS14020 (2853894) 2853894..2854088 - 195 WP_001295058.1 hypothetical protein -
QQG88_RS14025 (2854664) 2854664..2854852 + 189 WP_000449175.1 cell division inhibition protein DicB -
QQG88_RS14030 (2854849) 2854849..2855037 + 189 WP_000199475.1 DUF1482 family protein -
QQG88_RS14035 (2855130) 2855130..2857568 + 2439 WP_000102132.1 exonuclease -
QQG88_RS14040 (2857630) 2857630..2857899 + 270 WP_000003742.1 excisionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2835248..2862293 27045


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T297094 WP_001303511.1 NZ_OX637959:2852834-2853112 [Escherichia coli O25b:H4-ST131]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT297094 WP_001302048.1 NZ_OX637959:2852641-2852832 [Escherichia coli O25b:H4-ST131]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
AlphaFold DB A0A829CTP0

References