297093

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2410637..2412225 Replicon chromosome
Accession NZ_OX637959
Organism Escherichia coli O25b:H4-ST131 isolate 32

Toxin (Protein)


Gene name hipA Uniprot ID A0A061YM43
Locus tag QQG88_RS11660 Protein ID WP_001125411.1
Coordinates 2410903..2412225 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A061YNW4
Locus tag QQG88_RS11655 Protein ID WP_001296076.1
Coordinates 2410637..2410903 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQG88_RS11640 (2407005) 2407005..2408456 + 1452 WP_000854638.1 tagaturonate reductase -
QQG88_RS11645 (2408653) 2408653..2409567 + 915 WP_001296077.1 bestrophin family protein -
QQG88_RS11650 (2409571) 2409571..2410329 - 759 WP_001286537.1 trans-aconitate 2-methyltransferase -
QQG88_RS11655 (2410637) 2410637..2410903 + 267 WP_001296076.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QQG88_RS11660 (2410903) 2410903..2412225 + 1323 WP_001125411.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QQG88_RS11665 (2413135) 2413135..2413698 + 564 WP_001296074.1 type 1 fimbrial major subunit FimA -
QQG88_RS11670 (2414060) 2414060..2414770 + 711 WP_001195177.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49329.96 Da        Isoelectric Point: 7.7906

>T297093 WP_001125411.1 NZ_OX637959:2410903-2412225 [Escherichia coli O25b:H4-ST131]
MPKLVTWMNNQRVGELTKLANGAHTFKYAAEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHDRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9987.34 Da        Isoelectric Point: 4.9632

>AT297093 WP_001296076.1 NZ_OX637959:2410637-2410903 [Escherichia coli O25b:H4-ST131]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061YM43

Antitoxin

Source ID Structure
AlphaFold DB A0A061YNW4

References