Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 993409..994661 Replicon chromosome
Accession NZ_OX595791
Organism Streptococcus agalactiae isolate MRI Z2-270

Toxin (Protein)


Gene name sezT Uniprot ID A0A380JTF4
Locus tag QOY19_RS05120 Protein ID WP_001235243.1
Coordinates 993409..994185 (-) Length 259 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag QOY19_RS05125 Protein ID WP_000578714.1
Coordinates 994185..994661 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOY19_RS05110 989539..991356 - 1818 WP_000240881.1 ATP-dependent helicase -
QOY19_RS05115 991343..993412 - 2070 WP_003050786.1 AAA family ATPase -
QOY19_RS05120 993409..994185 - 777 WP_001235243.1 type II toxin-antitoxin system toxin PezT Toxin
QOY19_RS05125 994185..994661 - 477 WP_000578714.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
QOY19_RS05130 994731..995021 - 291 WP_003050790.1 hypothetical protein -
QOY19_RS05135 995071..995460 - 390 WP_003050791.1 DUF5945 family protein -
QOY19_RS05140 995457..995684 - 228 WP_003050793.1 DUF5965 family protein -
QOY19_RS05145 995738..996814 - 1077 WP_003050795.1 toprim domain-containing protein -
QOY19_RS05150 996853..997491 - 639 WP_003050797.1 hypothetical protein -
QOY19_RS05155 997587..997877 - 291 WP_003050799.1 DUF5966 family protein -
QOY19_RS05160 997891..998190 - 300 WP_003050801.1 DUF5962 family protein -
QOY19_RS05165 998262..999110 - 849 Protein_938 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(30-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 259 a.a.        Molecular weight: 29141.97 Da        Isoelectric Point: 5.7035

>T297080 WP_001235243.1 NZ_OX595791:c994185-993409 [Streptococcus agalactiae]
MRLEEFSEAEFQKALQRTVRALTRGKTILDKPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLKELESDKLFDQIQIYQRDRTCIYDSETDEGSAAEVLQECLFGKWSKVEEEML
KAGQERLCELVSGNGDKK

Download         Length: 777 bp

>T297080 NZ_OX595791:c994185-993409 [Streptococcus agalactiae]
ATGAGACTGGAAGAATTCAGTGAGGCTGAATTTCAGAAGGCCTTGCAACGAACCGTTCGGGCCTTAACCCGAGGAAAGAC
GATTCTAGATAAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGAGCAGGTAAGACAACGATACATCGTATCAAGCAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAGCATCCCAATTACTTAGCCCTGCAAGAA
AAGTATGGCAAAGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGATGAACTTAGCAC
ACAAGGTTATCATTTGCTGATTGAGGGAACCTTGCGAACTACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGCTTCTA
AAGGTTACCAAGTTTCTTTAGCTGTAATTGGTACCAAACCAGAATTGTCCTATCTCAGCACTCTGATTCGTTATGAAGAG
CTTTATGCCATAGATCCCAATCAGGCCAGAGCAACCCCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAAGGAGCTTGAAAGCGATAAACTCTTTGACCAGATTCAGATTTATCAAAGAGATAGAACTTGTATCTACGATTCTG
AAACTGATGAAGGCTCCGCAGCAGAAGTGCTACAAGAATGCCTCTTCGGAAAATGGAGCAAGGTAGAGGAAGAGATGTTG
AAGGCAGGACAGGAACGGTTGTGTGAATTAGTTTCAGGTAATGGAGATAAGAAATGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18305.72 Da        Isoelectric Point: 4.4743

>AT297080 WP_000578714.1 NZ_OX595791:c994661-994185 [Streptococcus agalactiae]
MIGDNIKSLRHTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKIE
VLKERGAAILSQLYRYQDSQDIAFDDETNPWILMSDDLAELIHTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp

>AT297080 NZ_OX595791:c994661-994185 [Streptococcus agalactiae]
ATGATTGGAGACAATATAAAATCACTACGCCATACACACGATTTAACACAACCAGAATTTGCGAAAATGGTCGGGATTTC
ACGCAATAGCCTGAGTCGTTATGAAAATGGGACCAGTACGGTTTCAACAGAGCTTATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGGGAGGATAAGATGCTAACACCTGTTGAAGATTACCAACTGACTTTAAAAATAGAA
GTGTTAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCAAGATATTGCTTTTGATGATGA
AACAAATCCTTGGATTTTGATGAGTGATGATTTGGCTGAATTGATCCATACGAAAATTTACCTTGTCGATACTTTCGATG
AAATTGAGCGTTATAATGGCTACTTAGACGGTATCGAACGGATGCTAGACATGGTGCATCATCGGGTGGTGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380JTF4

Antitoxin

Source ID Structure

References