Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 703254..703897 Replicon chromosome
Accession NC_021740
Organism Mycobacterium tuberculosis EAI5

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag M943_RS03175 Protein ID WP_003403187.1
Coordinates 703496..703897 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag M943_RS03170 Protein ID WP_003403184.1
Coordinates 703254..703499 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M943_RS03135 698534..699064 - 531 WP_003917320.1 two component system sensor kinase HK2 -
M943_RS03140 699048..699743 - 696 WP_200861092.1 response regulator transcription factor -
M943_RS03145 699866..700177 + 312 WP_003403164.1 hypothetical protein -
M943_RS03150 700249..701199 + 951 WP_003900184.1 DUF1259 domain-containing protein -
M943_RS03155 701440..702024 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
M943_RS03160 702026..702736 + 711 Protein_625 transposase -
M943_RS03165 702739..703209 + 471 WP_003898523.1 hypothetical protein -
M943_RS03170 703254..703499 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M943_RS03175 703496..703897 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
M943_RS21855 704285..704452 - 168 WP_077385191.1 DUF3800 domain-containing protein -
M943_RS21860 704485..704682 - 198 WP_003403191.1 hypothetical protein -
M943_RS03190 704762..705919 - 1158 WP_003898524.1 hypothetical protein -
M943_RS03195 705971..706192 - 222 WP_003898525.1 DUF4926 domain-containing protein -
M943_RS03200 706334..706939 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T29708 WP_003403187.1 NC_021740:703496-703897 [Mycobacterium tuberculosis EAI5]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T29708 NC_021740:703496-703897 [Mycobacterium tuberculosis EAI5]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT29708 WP_003403184.1 NC_021740:703254-703499 [Mycobacterium tuberculosis EAI5]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT29708 NC_021740:703254-703499 [Mycobacterium tuberculosis EAI5]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References