Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 249170..249782 Replicon chromosome
Accession NZ_OX595791
Organism Streptococcus agalactiae isolate MRI Z2-270

Toxin (Protein)


Gene name parE Uniprot ID Q8E1X3
Locus tag QOY19_RS01445 Protein ID WP_000384858.1
Coordinates 249170..249505 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E1X2
Locus tag QOY19_RS01450 Protein ID WP_000255538.1
Coordinates 249495..249782 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOY19_RS01420 244368..245009 + 642 WP_000591144.1 hypothetical protein -
QOY19_RS01425 245309..246184 + 876 WP_000421240.1 hypothetical protein -
QOY19_RS01430 246220..246654 + 435 WP_001220479.1 hypothetical protein -
QOY19_RS01435 246971..248227 + 1257 WP_000122836.1 MobV family relaxase -
QOY19_RS01440 248395..248865 + 471 WP_000130119.1 hypothetical protein -
QOY19_RS01445 249170..249505 - 336 WP_000384858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QOY19_RS01450 249495..249782 - 288 WP_000255538.1 hypothetical protein Antitoxin
QOY19_RS01455 250289..250579 + 291 WP_000078283.1 WXG100 family type VII secretion target -
QOY19_RS01460 250681..251088 + 408 WP_000749954.1 hypothetical protein -
QOY19_RS01465 251088..251648 + 561 WP_001865562.1 hypothetical protein -
QOY19_RS01470 251621..252301 + 681 WP_001865565.1 hypothetical protein -
QOY19_RS01475 252286..252672 + 387 WP_000259069.1 hypothetical protein -
QOY19_RS01480 252706..252987 + 282 WP_000052406.1 hypothetical protein -
QOY19_RS01485 253830..254690 + 861 WP_000477654.1 Rgg/GadR/MutR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 241198..250056 8858


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13264.04 Da        Isoelectric Point: 5.2388

>T297079 WP_000384858.1 NZ_OX595791:c249505-249170 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10921.47 Da        Isoelectric Point: 4.7271

>AT297079 WP_000255538.1 NZ_OX595791:c249782-249495 [Streptococcus agalactiae]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1EF10

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1EFF9

References