Detailed information of TA system TA297077

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1340828..1342260
• Replicon: chromosome
• Accession: NZ_OX465025
• Organism: Streptococcus agalactiae isolate MRI Z2-329

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: A0A0Z7ZBN7
• Locus tag: QWI70_RS06835
• Protein ID: WP_001030308.1
• Coordinates: 1341415..1342260 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: A0A0Z8TLJ4
• Locus tag: QWI70_RS06830
• Protein ID: WP_000037243.1
• Coordinates: 1340828..1341418 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QWI70_RS06830	1340828..1341418	+	591	WP_000037243.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QWI70_RS06835	1341415..1342260	+	846	WP_001030308.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QWI70_RS06840	1342323..1345124	-	2802	WP_000656696.1	phage tail tip lysozyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-257)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32530.30 Da
• Isoelectric Point: 5.2199

>T297077 WP_001030308.1 NZ_OX465025:1341415-1342260 [Streptococcus agalactiae]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRVTILCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFEKIIELLERFKSDP
IQNKQWQNYSKKYSYTKVISLADVLDEMIRLIAVLISINSD

Nucleotide

• Length: 846 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23237.83 Da
• Isoelectric Point: 8.3384

>AT297077 WP_000037243.1 NZ_OX465025:1340828-1341418 [Streptococcus agalactiae]
MSKKEILLEFIEKHKGIITYKDCKALNIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVNTPMGNEVRAYDFERIICDFVIHREKIDTELFVKT
LQHYGNYPKKNLTKLYEYATKMNTLAKVKQTLEVLV

Nucleotide

• Length: 591 bp

Structures

Toxin

• AlphaFold DB: A0A0Z7ZBN7

Antitoxin

• AlphaFold DB: A0A0Z8TLJ4