Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 239194..239806 Replicon chromosome
Accession NZ_OX465025
Organism Streptococcus agalactiae isolate MRI Z2-329

Toxin (Protein)


Gene name parE Uniprot ID Q8E1X3
Locus tag QWI70_RS01415 Protein ID WP_000384858.1
Coordinates 239194..239529 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E1X2
Locus tag QWI70_RS01420 Protein ID WP_000255538.1
Coordinates 239519..239806 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QWI70_RS01390 234380..235009 + 630 WP_000591148.1 hypothetical protein -
QWI70_RS01395 235333..236209 + 877 Protein_219 replication initiation protein -
QWI70_RS01400 236245..236679 + 435 WP_001220479.1 hypothetical protein -
QWI70_RS01405 236995..238251 + 1257 WP_000122832.1 MobV family relaxase -
QWI70_RS01410 238419..238889 + 471 WP_000130119.1 hypothetical protein -
QWI70_RS01415 239194..239529 - 336 WP_000384858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QWI70_RS01420 239519..239806 - 288 WP_000255538.1 hypothetical protein Antitoxin
QWI70_RS01425 240209..241429 - 1221 WP_000156558.1 site-specific integrase -
QWI70_RS01430 241490..241750 - 261 WP_001196072.1 helix-turn-helix domain-containing protein -
QWI70_RS01435 241762..242508 - 747 WP_000966632.1 hypothetical protein -
QWI70_RS01440 242694..243485 - 792 WP_001868842.1 hypothetical protein -
QWI70_RS01445 243466..243999 - 534 WP_000680721.1 hypothetical protein -
QWI70_RS01450 243999..244337 - 339 WP_001187920.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 190964..241534 50570


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13264.04 Da        Isoelectric Point: 5.2388

>T297076 WP_000384858.1 NZ_OX465025:c239529-239194 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10921.47 Da        Isoelectric Point: 4.7271

>AT297076 WP_000255538.1 NZ_OX465025:c239806-239519 [Streptococcus agalactiae]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1EF10

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1EFF9

References