Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4315340..4316881 Replicon chromosome
Accession NZ_OX461117
Organism Shewanella baltica strain SF1039 isolate SF1039

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QOT06_RS18420 Protein ID WP_283630272.1
Coordinates 4315340..4316641 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QOT06_RS18425 Protein ID WP_006086108.1
Coordinates 4316645..4316881 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOT06_RS18390 4310732..4310941 - 210 WP_138974004.1 hypothetical protein -
QOT06_RS18395 4310974..4311225 + 252 WP_006083102.1 DUF2999 family protein -
QOT06_RS18400 4311368..4311754 - 387 WP_283630268.1 carboxymuconolactone decarboxylase family protein -
QOT06_RS18405 4312103..4313503 + 1401 WP_283630269.1 GGDEF domain-containing protein -
QOT06_RS18410 4313616..4314038 - 423 WP_006086105.1 hypothetical protein -
QOT06_RS18415 4314568..4314837 - 270 WP_006086106.1 hypothetical protein -
QOT06_RS18420 4315340..4316641 - 1302 WP_283630272.1 HipA domain-containing protein Toxin
QOT06_RS18425 4316645..4316881 - 237 WP_006086108.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QOT06_RS18430 4317725..4317964 + 240 WP_006086109.1 alpha/beta hydrolase-fold protein -
QOT06_RS18435 4318040..4318225 + 186 WP_006086110.1 hypothetical protein -
QOT06_RS18440 4318277..4319452 - 1176 WP_283630275.1 HEAT repeat domain-containing protein -
QOT06_RS18445 4319872..4320888 + 1017 WP_283627786.1 IS110-like element ISSba19 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4319872..4320888 1016


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(146-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48676.98 Da        Isoelectric Point: 5.6584

>T297073 WP_283630272.1 NZ_OX461117:c4316641-4315340 [Shewanella baltica]
MSTSKKLTLEMHLGDLIIGELSFDAMTDTFAVHYTKDWQQSGFPLSPTIPLDGTGSSSQISMFLVNLLPENKGLDYLIES
LGVSKGNTFALIRAIGLDTAGAVAFVPKGTLLPETQLRPIKVEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYN
GEEFAFAEGALSSTHIVKFEKYRHLVLNEFMTMRLAKAIGMNVANVDIVHFGHYKVLCVERFDRRYMPNEQRVLRRHIVD
SCQALGFSVSKKYERNFGSGRDVKDIREGVSFNRLFSLAAKCRNPVAAKQDMLQWVLFNLLTGNADAHGKNYSFFMTASG
MEPTPWYDLVSVAMYEDFEQQLAMAIDDEFDPNSIFAYQLAAFIDGLGLPRNLLISNLTTIARRIPQAIDGVISMLPPLD
ENETSFVAHYKAQLLARCDRYLSFAAEVRDVEV

Download         Length: 1302 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8574.91 Da        Isoelectric Point: 7.9728

>AT297073 WP_006086108.1 NZ_OX461117:c4316881-4316645 [Shewanella baltica]
MASRLNQQSLGLLIKERRKSAALTQDVAAMLCGVTKKTLIRVEKGEDVYISTVFKILDGLGIEIVSAQTSDTETNGWY

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References