Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 4030..4611 Replicon plasmid EBP3064_p1
Accession NZ_OX461106
Organism Serratia proteamaculans strain EBP3064 isolate EBP3064

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QOT07_RS25195 Protein ID WP_283604460.1
Coordinates 4279..4611 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A328T8X3
Locus tag QOT07_RS25190 Protein ID WP_041691825.1
Coordinates 4030..4278 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOT07_RS25160 1..918 + 918 WP_283604454.1 plasmid replication initiator RepA -
QOT07_RS25165 1491..1733 + 243 WP_000124732.1 type II toxin-antitoxin system ParD family antitoxin -
QOT07_RS25170 1726..2010 + 285 WP_283604457.1 type II toxin-antitoxin system RelE/ParE family toxin -
QOT07_RS25175 2073..3017 - 945 WP_283604541.1 reverse transcriptase family protein -
QOT07_RS25180 2983..3300 - 318 WP_064645508.1 helix-turn-helix transcriptional regulator -
QOT07_RS25185 3333..3491 - 159 WP_211271130.1 hypothetical protein -
QOT07_RS25190 4030..4278 + 249 WP_041691825.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QOT07_RS25195 4279..4611 + 333 WP_283604460.1 endoribonuclease MazF Toxin
QOT07_RS25200 4653..4898 + 246 WP_283604462.1 hypothetical protein -
QOT07_RS25205 5082..5309 - 228 WP_283604464.1 plasmid partition protein ParG -
QOT07_RS25210 5349..5969 - 621 WP_283604466.1 ParA family partition ATPase -
QOT07_RS25215 6123..6260 - 138 WP_224718488.1 hypothetical protein -
QOT07_RS25220 6312..6917 - 606 WP_000509966.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..108855 108855


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(11-107)

Antitoxin

Antitoxin PemI-like

(4-81)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11953.73 Da        Isoelectric Point: 7.1059

>T297068 WP_283604460.1 NZ_OX461106:4279-4611 [Serratia proteamaculans]
MVSRYVPNSADLIWLDFDPVEGHEQGGHRPAVVLSPFSYNNPVGLLLCVPCTTKAKGYPFEVELSGSRESVALADQVTCV
DWRARKVTKKGAVSPEELAEIRAKAKALIG

Download         Length: 333 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8815.28 Da        Isoelectric Point: 5.7630

>AT297068 WP_041691825.1 NZ_OX461106:4030-4278 [Serratia proteamaculans]
MTTVTLKKWGNSPSIRIPASVMQAAALNVEDKLDLKIDEAGQIVLVPLKSKEYSLDVLLSGITPDNVHGKIDFGSPVGKE
LI

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A328T8X3

References