Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1671179..1671732 Replicon chromosome
Accession NZ_OX461105
Organism Serratia proteamaculans strain EBP3064 isolate EBP3064

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag QOT07_RS07885 Protein ID WP_099064106.1
Coordinates 1671418..1671732 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A379YKU0
Locus tag QOT07_RS07880 Protein ID WP_012005987.1
Coordinates 1671179..1671415 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOT07_RS07865 1667152..1668690 + 1539 WP_099064102.1 glutathione ABC transporter substrate-binding protein GsiB -
QOT07_RS07870 1668741..1669661 + 921 WP_085115922.1 glutathione ABC transporter permease GsiC -
QOT07_RS07875 1669671..1670579 + 909 WP_262261034.1 glutathione ABC transporter permease GsiD -
QOT07_RS07880 1671179..1671415 + 237 WP_012005987.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QOT07_RS07885 1671418..1671732 + 315 WP_099064106.1 CcdB family protein Toxin
QOT07_RS07890 1671769..1672611 - 843 WP_099064107.1 S-formylglutathione hydrolase -
QOT07_RS07895 1672626..1673753 - 1128 WP_198404463.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
QOT07_RS07900 1673781..1674698 - 918 WP_283602864.1 LysR substrate-binding domain-containing protein -
QOT07_RS07905 1674805..1675962 + 1158 WP_219015746.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11655.51 Da        Isoelectric Point: 4.7526

>T297057 WP_099064106.1 NZ_OX461105:1671418-1671732 [Serratia proteamaculans]
MQFTVYANTGKSTVYPLLLDVTSDIIGQLNRRVVIPLLPIEKYPGSTRPERLVPLVRLVDDNEYAVMTHEMASIPVRTLG
AEFCDATQYRTEVKAAIDFLLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9108.19 Da        Isoelectric Point: 6.7184

>AT297057 WP_012005987.1 NZ_OX461105:1671179-1671415 [Serratia proteamaculans]
MPVKQRTTQSVTMTVERSLLSRAREAGINLSATLNAALDAELRQHEMRKWKEDNREAIEALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A379YKU0

References