Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 286542..287154 Replicon chromosome
Accession NZ_OX461090
Organism Streptococcus agalactiae isolate MRI Z2-336

Toxin (Protein)


Gene name parE Uniprot ID A0A8G2N8L3
Locus tag OWO33_RS01700 Protein ID WP_000384860.1
Coordinates 286542..286877 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E7D2
Locus tag OWO33_RS01705 Protein ID WP_000259017.1
Coordinates 286867..287154 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OWO33_RS01675 281740..282381 + 642 WP_000591144.1 hypothetical protein -
OWO33_RS01680 282681..283556 + 876 WP_000421240.1 hypothetical protein -
OWO33_RS01685 283592..284026 + 435 WP_001220479.1 hypothetical protein -
OWO33_RS01690 284343..285599 + 1257 WP_000122836.1 MobV family relaxase -
OWO33_RS01695 285767..286237 + 471 WP_000130119.1 hypothetical protein -
OWO33_RS01700 286542..286877 - 336 WP_000384860.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OWO33_RS01705 286867..287154 - 288 WP_000259017.1 hypothetical protein Antitoxin
OWO33_RS01710 287661..287951 + 291 WP_000078283.1 WXG100 family type VII secretion target -
OWO33_RS01715 288053..288460 + 408 WP_000749954.1 hypothetical protein -
OWO33_RS01720 288460..289020 + 561 WP_001865562.1 hypothetical protein -
OWO33_RS01725 288993..289673 + 681 WP_001865565.1 hypothetical protein -
OWO33_RS01730 289658..290044 + 387 WP_000259069.1 hypothetical protein -
OWO33_RS01735 290078..290359 + 282 WP_000052406.1 hypothetical protein -
OWO33_RS01740 291202..292062 + 861 WP_000477654.1 Rgg/GadR/MutR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 192477..288440 95963


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13227.87 Da        Isoelectric Point: 4.5348

>T297048 WP_000384860.1 NZ_OX461090:c286877-286542 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10906.50 Da        Isoelectric Point: 4.7271

>AT297048 WP_000259017.1 NZ_OX461090:c287154-286867 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A076Z4V6

References