Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 1260929..1262361 Replicon chromosome
Accession NZ_OX461088
Organism Streptococcus agalactiae isolate MRI Z2-338

Toxin (Protein)


Gene name abiEi Uniprot ID A0A0Z7ZBN7
Locus tag QOR57_RS06560 Protein ID WP_001030308.1
Coordinates 1261516..1262361 (+) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID A0A0Z8TLJ4
Locus tag QOR57_RS06555 Protein ID WP_000037243.1
Coordinates 1260929..1261519 (+) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOR57_RS06555 1260929..1261519 + 591 WP_000037243.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
QOR57_RS06560 1261516..1262361 + 846 WP_001030308.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QOR57_RS06565 1262424..1265225 - 2802 WP_000656696.1 phage tail tip lysozyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-257)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32530.30 Da        Isoelectric Point: 5.2199

>T297047 WP_001030308.1 NZ_OX461088:1261516-1262361 [Streptococcus agalactiae]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRVTILCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFEKIIELLERFKSDP
IQNKQWQNYSKKYSYTKVISLADVLDEMIRLIAVLISINSD

Download         Length: 846 bp

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23237.83 Da        Isoelectric Point: 8.3384

>AT297047 WP_000037243.1 NZ_OX461088:1260929-1261519 [Streptococcus agalactiae]
MSKKEILLEFIEKHKGIITYKDCKALNIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVNTPMGNEVRAYDFERIICDFVIHREKIDTELFVKT
LQHYGNYPKKNLTKLYEYATKMNTLAKVKQTLEVLV

Download         Length: 591 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z7ZBN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8TLJ4

References