Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 1344329..1345764 Replicon chromosome
Accession NZ_OX460985
Organism Streptococcus agalactiae isolate MRI Z2-307

Toxin (Protein)


Gene name abiEi Uniprot ID Q8E4P3
Locus tag QOR59_RS06855 Protein ID WP_001030310.1
Coordinates 1344916..1345764 (+) Length 283 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID Q8E4P4
Locus tag QOR59_RS06850 Protein ID WP_000037314.1
Coordinates 1344329..1344919 (+) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOR59_RS06850 1344329..1344919 + 591 WP_000037314.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
QOR59_RS06855 1344916..1345764 + 849 WP_001030310.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QOR59_RS06860 1345868..1348663 - 2796 WP_001224270.1 phage tail tip lysozyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-267)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(7-51)


Sequences

Toxin        


Download         Length: 283 a.a.        Molecular weight: 32622.01 Da        Isoelectric Point: 5.6940

>T297046 WP_001030310.1 NZ_OX460985:1344916-1345764 [Streptococcus agalactiae]
MNKAKLTALCHKISKQTGLTFNSVMTYYFLEVILKKLSQSSYSDHYIFKGGFLLSNVIGVESRSTVDIDFLFNKQTLSGE
SIQRQLTEILAEDSKDDISFSIQSITAIKESDDYGGYRATILCQLENIKQMIHLDIATGDIVTPHPVTYDYKAIFDNKSF
PIIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKRQEINFSQLNIACQRTFSYRDTELNFNKLIELLETFKSD
AIQSQQWQNYSKKYSYTKGISFSDILDEIIDLLTDLNYENNH

Download         Length: 849 bp

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23040.43 Da        Isoelectric Point: 6.7184

>AT297046 WP_000037314.1 NZ_OX460985:1344329-1344919 [Streptococcus agalactiae]
MSKKEMLFDYLENHNGMITSKDCKTIGIPTIYLTRLENEGVIFRVEKGIYLSSTGDYDEYYFFQYRYPRTVFSYVSALYL
QGFTDEIPQYFEITVPKGYRFRNTPLNLNIHTVSKEFVNLGVISVETPVGNIVKVHDFERILCDFILNRDKIDSELFVKT
LQTYSNYSKKNTGKLYEYATKMNILDEVKRTLEVLL

Download         Length: 591 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8E4P3

Antitoxin

Source ID Structure
AlphaFold DB Q8E4P4

References