Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sezT-pezT/zeta-couple_hipB |
| Location | 1326703..1327949 | Replicon | chromosome |
| Accession | NZ_OX460985 | ||
| Organism | Streptococcus agalactiae isolate MRI Z2-307 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | - |
| Locus tag | QOR59_RS06785 | Protein ID | WP_000170757.1 |
| Coordinates | 1326703..1327473 (-) | Length | 257 a.a. |
Antitoxin (Protein)
| Gene name | pezT | Uniprot ID | Q8E4Q7 |
| Locus tag | QOR59_RS06790 | Protein ID | WP_000578715.1 |
| Coordinates | 1327473..1327949 (-) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QOR59_RS06770 | 1321734..1322093 | - | 360 | WP_011074740.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| QOR59_RS06775 | 1322428..1324446 | - | 2019 | WP_000222644.1 | ATP-dependent helicase | - |
| QOR59_RS06780 | 1324450..1326690 | - | 2241 | WP_000281027.1 | AAA family ATPase | - |
| QOR59_RS06785 | 1326703..1327473 | - | 771 | WP_000170757.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| QOR59_RS06790 | 1327473..1327949 | - | 477 | WP_000578715.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| QOR59_RS06795 | 1328019..1328309 | - | 291 | WP_001210630.1 | hypothetical protein | - |
| QOR59_RS06800 | 1328356..1328745 | - | 390 | WP_000132515.1 | DUF5945 family protein | - |
| QOR59_RS06805 | 1328742..1328972 | - | 231 | WP_000110918.1 | DUF5965 family protein | - |
| QOR59_RS06810 | 1329027..1330112 | - | 1086 | WP_000161120.1 | toprim domain-containing protein | - |
| QOR59_RS06815 | 1330153..1330791 | - | 639 | WP_000932868.1 | hypothetical protein | - |
| QOR59_RS06820 | 1330956..1331255 | - | 300 | WP_001147539.1 | DUF5966 family protein | - |
| QOR59_RS06825 | 1331266..1331565 | - | 300 | WP_000084342.1 | DUF5962 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | wbtL / lmb / scpB | 1247866..1341623 | 93757 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 257 a.a. Molecular weight: 29425.53 Da Isoelectric Point: 8.3930
>T297045 WP_000170757.1 NZ_OX460985:c1327473-1326703 [Streptococcus agalactiae]
MTLAEYSEAEFQKALRRNIRALTRGKTISSTPKAVLLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSFRSQHPNYLALQE
EYGKYSVDYTKDFAGKMVEHLIGELSKQSYHLLIEGTLRTTEVPRKTAQLLKSRGYQVSLALIATKPELSYLSTLIRYEE
LYAIDPNQARATPKEYHDGIVEHLVDNLRELENDKLFNRIQIYQRDRHCVYDSETDKGIAAEVLQECLFGKWSKVEEEML
RVGQERLRELSMRTPK
MTLAEYSEAEFQKALRRNIRALTRGKTISSTPKAVLLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSFRSQHPNYLALQE
EYGKYSVDYTKDFAGKMVEHLIGELSKQSYHLLIEGTLRTTEVPRKTAQLLKSRGYQVSLALIATKPELSYLSTLIRYEE
LYAIDPNQARATPKEYHDGIVEHLVDNLRELENDKLFNRIQIYQRDRHCVYDSETDKGIAAEVLQECLFGKWSKVEEEML
RVGQERLRELSMRTPK
Download Length: 771 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18145.47 Da Isoelectric Point: 4.4655
>AT297045 WP_000578715.1 NZ_OX460985:c1327949-1327473 [Streptococcus agalactiae]
MIGDNIKSLRRTHDLTQPEFAKIIGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEDKMMTPVEDYQLTIKIE
VLKERGSAILSRLYRHQDEQGIAFDDESNPWILISDDVADLVNTKIYLVDTFEELERYNGYLDGIERMLNLANHQVVA
MIGDNIKSLRRTHDLTQPEFAKIIGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEDKMMTPVEDYQLTIKIE
VLKERGSAILSRLYRHQDEQGIAFDDESNPWILISDDVADLVNTKIYLVDTFEELERYNGYLDGIERMLNLANHQVVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|