297038

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1491..2010 Replicon plasmid MIP2461_p2
Accession NZ_OX460965
Organism Hafnia paralvei strain MIP2461 isolate MIP2461

Toxin (Protein)


Gene name parE Uniprot ID A0A837F4A9
Locus tag QOT00_RS22765 Protein ID WP_000277490.1
Coordinates 1726..2010 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A6P1V8C3
Locus tag QOT00_RS22760 Protein ID WP_000124732.1
Coordinates 1491..1733 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOT00_RS22755 1..918 + 918 WP_064645521.1 plasmid replication initiator RepA -
QOT00_RS22760 1491..1733 + 243 WP_000124732.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
QOT00_RS22765 1726..2010 + 285 WP_000277490.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QOT00_RS22770 2344..2712 + 369 WP_032677090.1 hypothetical protein -
QOT00_RS22775 2861..3028 - 168 WP_179289137.1 hypothetical protein -
QOT00_RS22780 2948..3370 + 423 Protein_5 phosphodiesterase MrkJ -
QOT00_RS22785 3405..4040 - 636 WP_000677445.1 type 3 fimbria minor subunit MrkF -
QOT00_RS22790 4054..5049 - 996 WP_050296622.1 type 3 fimbria adhesin subunit MrkD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mrkJ / mrkF / mrkD / mrkC / mrkB / mrkA 1..39765 39765


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-88)

Antitoxin

Antitoxin ParD

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11005.52 Da        Isoelectric Point: 6.2103

>T297038 WP_000277490.1 NZ_OX460965:1726-2010 [Hafnia paralvei]
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHTVPGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8875.01 Da        Isoelectric Point: 7.0130

>AT297038 WP_000124732.1 NZ_OX460965:1491-1733 [Hafnia paralvei]
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F4A9

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V8C3

References