Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 4613204..4613925 Replicon chromosome
Accession NZ_OX460963
Organism Hafnia paralvei strain MIP2461 isolate MIP2461

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag QOT00_RS21340 Protein ID WP_047399350.1
Coordinates 4613204..4613545 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0A0FFR4
Locus tag QOT00_RS21345 Protein ID WP_045265421.1
Coordinates 4613581..4613925 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOT00_RS21320 4609795..4610832 - 1038 WP_045265419.1 virulence RhuM family protein -
QOT00_RS21325 4610920..4611240 - 321 Protein_4151 DUF4942 domain-containing protein -
QOT00_RS21335 4612571..4613089 - 519 Protein_4153 DUF4942 domain-containing protein -
QOT00_RS21340 4613204..4613545 - 342 WP_047399350.1 TA system toxin CbtA family protein Toxin
QOT00_RS21345 4613581..4613925 - 345 WP_045265421.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QOT00_RS21350 4613949..4614170 - 222 WP_047399352.1 DUF987 family protein -
QOT00_RS21355 4614181..4614654 - 474 WP_047399355.1 DNA repair protein RadC -
QOT00_RS21360 4614725..4615546 - 822 WP_283648209.1 DUF932 domain-containing protein -
QOT00_RS21365 4615615..4616070 - 456 WP_047399359.1 hypothetical protein -
QOT00_RS21370 4616302..4617105 - 804 WP_045265426.1 hypothetical protein -
QOT00_RS21375 4617125..4617559 - 435 WP_045265427.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(14-113)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12748.67 Da        Isoelectric Point: 8.5196

>T297036 WP_047399350.1 NZ_OX460963:c4613545-4613204 [Hafnia paralvei]
MNTSPATNQRVAKPCPSPVAVWQMLLTRLLAQHYGLALSDTPFCDETVIQEHINAGVTLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQAMGLLRQGHNLSTR

Download         Length: 342 bp

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12867.88 Da        Isoelectric Point: 8.1459

>AT297036 WP_045265421.1 NZ_OX460963:c4613925-4613581 [Hafnia paralvei]
MKKDTANEVVDTLRWGLKCDITPHFGARLVQEGNRLHYLADRASIIGPFSKADLRHLNQAFPLLMKQMELMLTSGELNSR
HQHCVTLYAKGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 345 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0A0FFR4

References