Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4118301..4118868 Replicon chromosome
Accession NZ_OX460963
Organism Hafnia paralvei strain MIP2461 isolate MIP2461

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QOT00_RS19165 Protein ID WP_105375245.1
Coordinates 4118301..4118435 (+) Length 45 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G9YED8
Locus tag QOT00_RS19170 Protein ID WP_004097419.1
Coordinates 4118458..4118868 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOT00_RS19145 4113469..4114575 + 1107 WP_008815234.1 transglutaminase domain-containing protein -
QOT00_RS19150 4114626..4115144 - 519 WP_283648121.1 cytochrome b/b6 domain-containing protein -
QOT00_RS19155 4115147..4115539 - 393 WP_039184830.1 cytochrome b562 -
QOT00_RS19160 4116574..4117914 - 1341 WP_008815237.1 metalloprotease PmbA -
QOT00_RS19165 4118301..4118435 + 135 WP_105375245.1 type II toxin-antitoxin system HicA family toxin Toxin
QOT00_RS19170 4118458..4118868 + 411 WP_004097419.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QOT00_RS19175 4118973..4119530 + 558 WP_039184825.1 ribosome biogenesis factor YjgA -
QOT00_RS19180 4119610..4119888 - 279 WP_039184822.1 barstar family protein -
QOT00_RS19185 4119894..4120352 - 459 WP_008815240.1 ribonuclease domain-containing protein -
QOT00_RS19190 4120612..4122102 - 1491 WP_048797737.1 NAD-dependent succinate-semialdehyde dehydrogenase -
QOT00_RS19195 4122399..4123793 - 1395 WP_193764060.1 ATP-dependent RNA helicase DbpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(2-44)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4901.75 Da        Isoelectric Point: 11.9239

>T297034 WP_105375245.1 NZ_OX460963:4118301-4118435 [Hafnia paralvei]
ILKRVKGSHHHFTHPNKTGLVTIPHPKKDLPANTVKSIRQQAGL

Download         Length: 135 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14951.18 Da        Isoelectric Point: 4.5106

>AT297034 WP_004097419.1 NZ_OX460963:4118458-4118868 [Hafnia paralvei]
MLYPIAIESGDQHHAYGVTVPDLPGCFSAGDTLDEAIANAKQAIISHIELLVEMEADFPMPSKIEDLSNKAEYQEYIWAI
VEVDVTRLMGGAEKINVTLPKSLIARIDRVVALHPEYKSRSGFLAQAALEQVTVIK

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G9YED8

References