Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3480467..3481058 Replicon chromosome
Accession NZ_OX460963
Organism Hafnia paralvei strain MIP2461 isolate MIP2461

Toxin (Protein)


Gene name Hha Uniprot ID G9Y5B5
Locus tag QOT00_RS16250 Protein ID WP_004091739.1
Coordinates 3480855..3481058 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A4Q9EVH1
Locus tag QOT00_RS16245 Protein ID WP_008814252.1
Coordinates 3480467..3480841 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOT00_RS16230 3476225..3479377 + 3153 WP_039188527.1 multidrug efflux RND transporter permease subunit AcrB -
QOT00_RS16235 3479538..3479810 + 273 WP_004091742.1 type B 50S ribosomal protein L31 -
QOT00_RS16240 3479810..3479950 + 141 WP_020303633.1 type B 50S ribosomal protein L36 -
QOT00_RS16245 3480467..3480841 + 375 WP_008814252.1 Hha toxicity modulator TomB Antitoxin
QOT00_RS16250 3480855..3481058 + 204 WP_004091739.1 HHA domain-containing protein Toxin
QOT00_RS16260 3482003..3482335 + 333 WP_130954960.1 MGMT family protein -
QOT00_RS16265 3482393..3482911 - 519 WP_008814254.1 YbaY family lipoprotein -
QOT00_RS16270 3483224..3484084 + 861 WP_008814255.1 acyl-CoA thioesterase II -
QOT00_RS16275 3484148..3485437 - 1290 WP_039188520.1 ammonium transporter AmtB -
QOT00_RS16280 3485471..3485809 - 339 WP_004091732.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8119.38 Da        Isoelectric Point: 5.8346

>T297033 WP_004091739.1 NZ_OX460963:3480855-3481058 [Hafnia paralvei]
MTKIDYLMRLRKCTTLDTLERVIEKNKYELSDDELETFYSAADHRLAELTMNKLYDKIPAEVWKYVR

Download         Length: 204 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14447.17 Da        Isoelectric Point: 4.4776

>AT297033 WP_008814252.1 NZ_OX460963:3480467-3480841 [Hafnia paralvei]
MDEYTSYQHDITELKYLCNMLYNQGMDVLSDSHHGWVNDPTAVDNLQLNELNEHIANFGLTFKIKYPNASELTEILDEYL
DETYSLFSNYSINEPELKKWLKAKGRILRYLAGEKTTSALNFNL

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G9Y5B5

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q9EVH1

References