297027

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 921711..922372 Replicon chromosome
Accession NZ_OX460963
Organism Hafnia paralvei strain MIP2461 isolate MIP2461

Toxin (Protein)


Gene name ypjF Uniprot ID S3IMJ6
Locus tag QOT00_RS04370 Protein ID WP_000698542.1
Coordinates 922049..922372 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID S3J179
Locus tag QOT00_RS04365 Protein ID WP_000065326.1
Coordinates 921711..922028 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOT00_RS04320 916851..917675 + 825 WP_000197385.1 DUF932 domain-containing protein -
QOT00_RS04325 917884..918594 + 711 WP_024198336.1 hypothetical protein -
QOT00_RS04330 918620..919156 + 537 WP_000219797.1 DUF4339 domain-containing protein -
QOT00_RS04335 919198..919635 + 438 WP_024198335.1 hypothetical protein -
QOT00_RS04340 919702..920112 + 411 WP_000912997.1 hypothetical protein -
QOT00_RS04345 920190..920426 + 237 WP_000004273.1 DUF905 domain-containing protein -
QOT00_RS04350 920512..920970 + 459 WP_016538084.1 antirestriction protein -
QOT00_RS04355 920986..921462 + 477 WP_000811694.1 RadC family protein -
QOT00_RS04360 921471..921692 + 222 WP_000691995.1 DUF987 domain-containing protein -
QOT00_RS04365 921711..922028 + 318 WP_000065326.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QOT00_RS04370 922049..922372 + 324 WP_000698542.1 TA system toxin CbtA family protein Toxin
QOT00_RS04375 923062..923766 - 705 WP_008815084.1 CZB domain-containing protein -
QOT00_RS04380 924174..925244 - 1071 WP_020303490.1 hypothetical protein -
QOT00_RS04385 925285..925812 - 528 WP_283647558.1 fimbrial protein -
QOT00_RS04390 925799..926500 - 702 WP_095661578.1 fimbrial chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 903344..931551 28207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12350.38 Da        Isoelectric Point: 8.9789

>T297027 WP_000698542.1 NZ_OX460963:922049-922372 [Hafnia paralvei]
MKILPATISRAAKPCLPPVAVWQLLLTRLLEKHYGLTLNDTPFSDETVIKEHFDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTPYLTNIDIMRARRDLGLLNRN

Download         Length: 324 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11830.50 Da        Isoelectric Point: 6.9367

>AT297027 WP_000065326.1 NZ_OX460963:921711-922028 [Hafnia paralvei]
MSNIIWGLQRDITPRLGTRLVQEGNQLHYLADRACITGKFSDAECLKLDVAFPHFISRMESMLSTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYVAVYSTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3IMJ6

Antitoxin

Source ID Structure
AlphaFold DB S3J179

References