Detailed information of TA system TA297024

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1453877..1455309
• Replicon: chromosome
• Accession: NZ_OX460960
• Organism: Streptococcus agalactiae isolate MRI Z2-299

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: A0A829IAV6
• Locus tag: QOR61_RS07520
• Protein ID: WP_001030309.1
• Coordinates: 1454464..1455309 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: A0A829IE45
• Locus tag: QOR61_RS07515
• Protein ID: WP_000037244.1
• Coordinates: 1453877..1454467 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QOR61_RS07515	1453877..1454467	+	591	WP_000037244.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QOR61_RS07520	1454464..1455309	+	846	WP_001030309.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QOR61_RS07525	1455371..1458172	-	2802	WP_047212107.1	phage tail tip lysozyme	-
QOR61_RS07530	1458174..1459055	-	882	Protein_1407	type IV secretion system protein VirB4	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32504.22 Da
• Isoelectric Point: 5.7639

>T297024 WP_001030309.1 NZ_OX460960:1454464-1455309 [Streptococcus agalactiae]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHRITLSEE
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLRNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD

Nucleotide

• Length: 846 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23221.78 Da
• Isoelectric Point: 7.3114

>AT297024 WP_000037244.1 NZ_OX460960:1453877-1454467 [Streptococcus agalactiae]
MSKKEILLEFIENHNGIITYKDCKALNIPTIYLTRLEKEGIIYRIEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSDLGITLVKTPMGNEVKVYDLERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV

Nucleotide

• Length: 591 bp

Structures

Toxin

• AlphaFold DB: A0A829IAV6

Antitoxin

• AlphaFold DB: A0A829IE45