Detailed information of TA system TA297023

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1436230..1437494
• Replicon: chromosome
• Accession: NZ_OX460960
• Organism: Streptococcus agalactiae isolate MRI Z2-299

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A829IH49
• Locus tag: QOR61_RS07450
• Protein ID: WP_001235241.1
• Coordinates: 1436230..1437018 (-)
• Length: 263 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: QOR61_RS07455
• Protein ID: WP_000578721.1
• Coordinates: 1437018..1437494 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QOR61_RS07415	1431295..1431660	-	366	WP_000431640.1	MobC family plasmid mobilization relaxosome protein	-
QOR61_RS07420	1431663..1432025	-	363	WP_000140674.1	SAG1252 family conjugative relaxosome accessory protein	-
QOR61_RS07425	1432363..1432539	-	177	WP_001873137.1	hypothetical protein	-
QOR61_RS07430	1432545..1432955	-	411	WP_001873139.1	hypothetical protein	-
QOR61_RS07435	1432952..1434118	-	1167	WP_239658011.1	UvrD-helicase domain-containing protein	-
QOR61_RS07440	1434290..1434493	-	204	WP_239658010.1	UvrD-helicase domain-containing protein	-
QOR61_RS07445	1434486..1436240	-	1755	WP_000394601.1	AAA family ATPase	-
QOR61_RS07450	1436230..1437018	-	789	WP_001235241.1	type II toxin-antitoxin system toxin PezT	Toxin
QOR61_RS07455	1437018..1437494	-	477	WP_000578721.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
QOR61_RS07460	1437564..1437854	-	291	WP_025193267.1	hypothetical protein	-
QOR61_RS07465	1437910..1438299	-	390	WP_000048065.1	DUF5945 family protein	-
QOR61_RS07470	1438296..1438523	-	228	WP_000110921.1	DUF5965 family protein	-
QOR61_RS07475	1438577..1439653	-	1077	WP_000196870.1	toprim domain-containing protein	-
QOR61_RS07480	1439693..1440331	-	639	WP_000933068.1	hypothetical protein	-
QOR61_RS07485	1440427..1440717	-	291	WP_000893085.1	DUF5966 family protein	-
QOR61_RS07490	1440731..1441030	-	300	WP_000194866.1	DUF5962 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (30-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 263 a.a.
• Molecular weight: 29768.79 Da
• Isoelectric Point: 6.2496

>T297023 WP_001235241.1 NZ_OX460960:c1437018-1436230 [Streptococcus agalactiae]
MRLEEFSEADFQKALQRTIRALTRGKTIPVQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLTSKGYQVSLAIIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKDHHDGIVENLVDNLRELEREQLFDQIQIYQRDRACIYDSETDEGSAAEVLQDCLFGKCSKVEEEMM
KLGRERLVKLNNKNLLESNYGI

Nucleotide

• Length: 789 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18256.69 Da
• Isoelectric Point: 4.4582

>AT297023 WP_000578721.1 NZ_OX460960:c1437494-1437018 [Streptococcus agalactiae]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQNIAFDDEANPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

Structures

Toxin

• AlphaFold DB: A0A829IH49