Detailed information of TA system TA297018

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1318332..1319764
• Replicon: chromosome
• Accession: NZ_OX460943
• Organism: Streptococcus agalactiae isolate MRI Z2-328

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: QOR52_RS06700
• Protein ID: WP_041980506.1
• Coordinates: 1318919..1319764 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: QOR52_RS06695
• Protein ID: WP_041980508.1
• Coordinates: 1318332..1318922 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QOR52_RS06695	1318332..1318922	+	591	WP_041980508.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QOR52_RS06700	1318919..1319764	+	846	WP_041980506.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QOR52_RS06705	1319826..1322627	-	2802	WP_283572361.1	phage tail tip lysozyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32480.25 Da
• Isoelectric Point: 5.7560

>T297018 WP_041980506.1 NZ_OX460943:1318919-1319764 [Streptococcus agalactiae]
MNKAKLTALCHKLSKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQMTLSED
TVKQQLKEILADSEEGISFVIQSTTAIKESDDYGGYRATILCQLENIKQIIHLDIATGDIVTPQPITYDYKAIFNEDTFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD

Nucleotide

• Length: 846 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23089.71 Da
• Isoelectric Point: 8.7432

>AT297018 WP_041980508.1 NZ_OX460943:1318332-1318922 [Streptococcus agalactiae]
MSKKEILLDFIEKNNGIITNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNKVRVYDLERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV

Nucleotide

• Length: 591 bp