Detailed information of TA system TA297015

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1325540..1326972
• Replicon: chromosome
• Accession: NZ_OX460941
• Organism: Streptococcus agalactiae isolate MRI Z2-304

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: QOR58_RS06905
• Protein ID: WP_283571615.1
• Coordinates: 1326127..1326972 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: QOR58_RS06900
• Protein ID: WP_000037245.1
• Coordinates: 1325540..1326130 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QOR58_RS06900	1325540..1326130	+	591	WP_000037245.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QOR58_RS06905	1326127..1326972	+	846	WP_283571615.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QOR58_RS06910	1327035..1329836	-	2802	WP_283571616.1	phage tail tip lysozyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1276678..1352023	75345

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-257)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32476.07 Da
• Isoelectric Point: 4.9373

>T297015 WP_283571615.1 NZ_OX460941:1326127-1326972 [Streptococcus agalactiae]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSED
TVEQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATILCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFEKIIELLERFKSDT
IQNKQWQNYSKKYSYTKGISLTDVLDEMIHLIAVLISINSD

Nucleotide

• Length: 846 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23268.93 Da
• Isoelectric Point: 8.3396

>AT297015 WP_000037245.1 NZ_OX460941:1325540-1326130 [Streptococcus agalactiae]
MSKKEILLEFIENHNGIITYKDCKALNIPTIYLTRLEKEGIIYRVEKGIFLTQNGDYDEYFFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDITIPRGYRFNTPPANLNIHSVSKKYSELGITLVKTPMGNEVRVYDFERIICDFVIHREKIDTELFVKT
LQLYGNYPKKNLTKLYEYATKMNTLDKVKQTLEVLV

Nucleotide

• Length: 591 bp