Detailed information of TA system TA297014

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1301562..1302808
• Replicon: chromosome
• Accession: NZ_OX460941
• Organism: Streptococcus agalactiae isolate MRI Z2-304

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: QOR58_RS06805
• Protein ID: WP_283571608.1
• Coordinates: 1301562..1302332 (-)
• Length: 257 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A2X3RVP4
• Locus tag: QOR58_RS06810
• Protein ID: WP_043029979.1
• Coordinates: 1302332..1302808 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QOR58_RS06775	1296842..1297519	-	678	WP_000276694.1	response regulator transcription factor	-
QOR58_RS06780	1297740..1299620	-	1881	WP_283571607.1	SAG1250 family conjugative relaxase	-
QOR58_RS06785	1299607..1299972	-	366	WP_000263042.1	MobC family plasmid mobilization relaxosome protein	-
QOR58_RS06790	1299982..1300341	-	360	WP_115245851.1	SAG1252 family conjugative relaxosome accessory protein	-
QOR58_RS06795	1300700..1301068	-	369	WP_052495489.1	hypothetical protein	-
QOR58_RS06800	1301059..1301559	-	501	WP_052495490.1	hypothetical protein	-
QOR58_RS06805	1301562..1302332	-	771	WP_283571608.1	type II toxin-antitoxin system toxin PezT	Toxin
QOR58_RS06810	1302332..1302808	-	477	WP_043029979.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
QOR58_RS06815	1302878..1303165	-	288	WP_283571609.1	hypothetical protein	-
QOR58_RS06820	1303210..1303605	-	396	WP_043029980.1	DUF5945 family protein	-
QOR58_RS06825	1303609..1303836	-	228	WP_043029981.1	DUF5965 family protein	-
QOR58_RS06830	1303890..1304978	-	1089	WP_043029982.1	toprim domain-containing protein	-
QOR58_RS06835	1305017..1305655	-	639	WP_283571697.1	peptidylprolyl isomerase	-
QOR58_RS06840	1305768..1307030	-	1263	WP_043029983.1	MATE family efflux transporter	-
QOR58_RS06845	1307030..1307350	-	321	WP_043029984.1	PqqD family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1276678..1352023	75345

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 257 a.a.
• Molecular weight: 29045.83 Da
• Isoelectric Point: 5.6385

>T297014 WP_283571608.1 NZ_OX460941:c1302332-1301562 [Streptococcus agalactiae]
MRLEEFSQDDFDLALKRTIRSLTRGKTTSVSPKAILLGGQSGAGKTTIHRIEQKEFQGNIIIIDGDSYRSLHPNYLALHE
EYGKDSVDYTKGFAGKMVEHLVDDLSKQGYHLLIEGTLRTTEVPRKTARLLNSRGYQVSLALIATKPELSYLSTLICYEE
VYAVNPNQARATPKEHHDGIVDHLVDNLRELENDKLFGQIQIYQRDRTCVYDSKTDEGSAADVLQECLFGKWSKVEEEML
KVGQECLRELEFKGEC

Nucleotide

• Length: 771 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18046.41 Da
• Isoelectric Point: 4.3193

>AT297014 WP_043029979.1 NZ_OX460941:c1302808-1302332 [Streptococcus agalactiae]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEEKLLTPVEDYQLTLKIE
VIKERGAAILSELYCYQDSQGIAFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELARHQVVA

Nucleotide

• Length: 477 bp

Structures

Antitoxin

• AlphaFold DB: A0A2X3RVP4