Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 2110581..2111205 Replicon chromosome
Accession NZ_OX460938
Organism Streptococcus agalactiae isolate MRI Z2-318

Toxin (Protein)


Gene name parE Uniprot ID A0A076ZDW1
Locus tag QOR49_RS10650 Protein ID WP_000253103.1
Coordinates 2110581..2110928 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A076YVN5
Locus tag QOR49_RS10655 Protein ID WP_000543070.1
Coordinates 2110918..2111205 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOR49_RS10630 2106296..2106652 - 357 WP_000105934.1 DUF1304 domain-containing protein -
QOR49_RS10635 2106719..2109037 - 2319 WP_283572725.1 YhgE/Pip domain-containing protein -
QOR49_RS10640 2109176..2109715 + 540 WP_000245858.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
QOR49_RS10645 2109801..2110097 - 297 WP_001052249.1 DUF4298 domain-containing protein -
QOR49_RS10650 2110581..2110928 - 348 WP_000253103.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QOR49_RS10655 2110918..2111205 - 288 WP_000543070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QOR49_RS10660 2111274..2111651 - 378 WP_000038826.1 ArpU family phage packaging/lysis transcriptional regulator -
QOR49_RS10665 2111626..2111778 - 153 Protein_2031 DUF1492 domain-containing protein -
QOR49_RS10670 2111785..2112273 - 489 WP_000891151.1 hypothetical protein -
QOR49_RS10675 2112346..2112903 - 558 WP_001258765.1 hypothetical protein -
QOR49_RS10680 2113061..2113234 - 174 WP_000694573.1 hypothetical protein -
QOR49_RS10685 2113231..2113488 - 258 WP_001069293.1 hypothetical protein -
QOR49_RS10690 2113781..2115175 - 1395 WP_000656430.1 VapE family protein -
QOR49_RS10695 2115187..2116044 - 858 WP_001029296.1 primase alpha helix C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2105419..2124379 18960


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(12-108)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-63)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13333.09 Da        Isoelectric Point: 5.1643

>T297009 WP_000253103.1 NZ_OX460938:c2110928-2110581 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Download         Length: 348 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10605.98 Da        Isoelectric Point: 4.8430

>AT297009 WP_000543070.1 NZ_OX460938:c2111205-2110918 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A076ZDW1

Antitoxin

Source ID Structure
AlphaFold DB A0A076YVN5

References