Detailed information of TA system TA297007

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1317249..1318672
• Replicon: chromosome
• Accession: NZ_OX460935
• Organism: Streptococcus agalactiae isolate MRI Z2-286

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: QOR45_RS06710
• Protein ID: WP_111715775.1
• Coordinates: 1317836..1318672 (+)
• Length: 279 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: QOR45_RS06705
• Protein ID: WP_111715777.1
• Coordinates: 1317249..1317839 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QOR45_RS06690	1313879..1315792	+	1914	WP_070039954.1	PT domain-containing protein	-
QOR45_RS06695	1315779..1316006	+	228	WP_017650313.1	hypothetical protein	-
QOR45_RS06700	1316025..1317137	+	1113	WP_283572187.1	phage tail tip lysozyme	-
QOR45_RS06705	1317249..1317839	+	591	WP_111715777.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QOR45_RS06710	1317836..1318672	+	837	WP_111715775.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QOR45_RS06715	1318857..1319054	+	198	WP_006738512.1	excisionase	-
QOR45_RS06720	1319119..1320369	+	1251	WP_283572188.1	site-specific integrase	-
QOR45_RS06725	1320607..1321077	-	471	WP_000152413.1	6,7-dimethyl-8-ribityllumazine synthase	-
QOR45_RS06730	1321092..1322285	-	1194	WP_000885817.1	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	-
QOR45_RS06735	1322303..1322953	-	651	WP_000493859.1	riboflavin synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-263)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (7-52)

Sequences

Toxin

Protein

• Length: 279 a.a.
• Molecular weight: 31937.34 Da
• Isoelectric Point: 5.1824

>T297007 WP_111715775.1 NZ_OX460935:1317836-1318672 [Streptococcus agalactiae]
VNKAKLTALCHKVSKETGLTFNSVMTYYFLEIILKKLSQSAYAQNYIFKGGFLLSNVVGVASRSTVDIDFLFSKMNLSEE
TVHQQLEDILGKSDEDISFTIQSVTAIKESDDYGGYRASILCQLENIRQVIHLDIATGDIVTPQPITYDYKPIFTSEQFP
IIAYTIETILAEKLQTIYSRSFLNSRSKDFYDIYILSKLKKSEIDSQQLLTACQRTFDYRGTELDFDKFINLLETFKTDS
TQNHQWENYSKKYSYTKGITFNDVLTEMTDLLVTIKNL

Nucleotide

• Length: 837 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23193.56 Da
• Isoelectric Point: 8.3205

>AT297007 WP_111715777.1 NZ_OX460935:1317249-1317839 [Streptococcus agalactiae]
MSNKETVLNYLKQNNGIITYKDCKELGVPAVYLSRLENEEKIFRVDKGIYLSTDGDYDEYYFFQYRFSRAIYSYVSALYL
QGFTDEIPQYFEVTVPRGYRFNNPPQNLAVHTVPKEIVDLGIISIKTPWGQTVKTYDFERIICDFIQNRKKIDNELFVKT
LKAYVNYPNKNLTNLYQYAEKMKIINQTKQTLEVLM

Nucleotide

• Length: 591 bp