297006

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 2123185..2123809 Replicon chromosome
Accession NZ_OX460934
Organism Streptococcus agalactiae isolate MRI Z2-335

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QOR46_RS10700 Protein ID WP_000253104.1
Coordinates 2123185..2123532 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A076YVN5
Locus tag QOR46_RS10705 Protein ID WP_000543070.1
Coordinates 2123522..2123809 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOR46_RS10680 2118901..2119257 - 357 WP_000105933.1 DUF1304 domain-containing protein -
QOR46_RS10685 2119324..2121642 - 2319 WP_000883422.1 YhgE/Pip domain-containing protein -
QOR46_RS10690 2121781..2122320 + 540 WP_000245863.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
QOR46_RS10695 2122406..2122702 - 297 WP_000365227.1 DUF4298 domain-containing protein -
QOR46_RS10700 2123185..2123532 - 348 WP_000253104.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QOR46_RS10705 2123522..2123809 - 288 WP_000543070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QOR46_RS10710 2123878..2124255 - 378 WP_000038826.1 ArpU family phage packaging/lysis transcriptional regulator -
QOR46_RS10715 2124230..2124382 - 153 Protein_2040 DUF1492 domain-containing protein -
QOR46_RS10720 2124389..2124877 - 489 WP_000891152.1 hypothetical protein -
QOR46_RS10725 2124950..2125507 - 558 WP_001258771.1 hypothetical protein -
QOR46_RS10730 2125509..2125682 - 174 WP_000768928.1 hypothetical protein -
QOR46_RS10735 2125688..2125861 - 174 WP_000694578.1 hypothetical protein -
QOR46_RS10740 2126195..2127697 - 1503 WP_000838185.1 DNA primase family protein -
QOR46_RS10745 2127717..2128574 - 858 WP_001029300.1 primase C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2118024..2152071 34047


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(12-108)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-63)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13381.18 Da        Isoelectric Point: 5.5857

>T297006 WP_000253104.1 NZ_OX460934:c2123532-2123185 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSYIIHSKQDYIKLFKKK

Download         Length: 348 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10605.98 Da        Isoelectric Point: 4.8430

>AT297006 WP_000543070.1 NZ_OX460934:c2123809-2123522 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A076YVN5

References