Detailed information of TA system TA297005

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1394189..1395621
• Replicon: chromosome
• Accession: NZ_OX460934
• Organism: Streptococcus agalactiae isolate MRI Z2-335

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: A0A4V0H4S0
• Locus tag: QOR46_RS07155
• Protein ID: WP_017648293.1
• Coordinates: 1394776..1395621 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: A0A0Z8F079
• Locus tag: QOR46_RS07150
• Protein ID: WP_017648292.1
• Coordinates: 1394189..1394779 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QOR46_RS07150	1394189..1394779	+	591	WP_017648292.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QOR46_RS07155	1394776..1395621	+	846	WP_017648293.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QOR46_RS07160	1395683..1398484	-	2802	WP_017648294.1	phage tail tip lysozyme	-
QOR46_RS07165	1398486..1399367	-	882	Protein_1334	type IV secretion system protein VirB4	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32466.14 Da
• Isoelectric Point: 5.4360

>T297005 WP_017648293.1 NZ_OX460934:1394776-1395621 [Streptococcus agalactiae]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQMTLSED
TVKQQLKEILADSEEGISFVIQSVTAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLRNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD

Nucleotide

• Length: 846 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23295.83 Da
• Isoelectric Point: 7.3108

>AT297005 WP_017648292.1 NZ_OX460934:1394189-1394779 [Streptococcus agalactiae]
MSKKEILLEFIENHNGIITYKDCKALNIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNEVRVYDFERIICDFVIHREKIDTELFVKT
LQHYGNYPKKNLTKLYEYATKMNTLDKVKQTLEVLV

Nucleotide

• Length: 591 bp

Structures

Toxin

• AlphaFold DB: A0A4V0H4S0

Antitoxin

• AlphaFold DB: A0A0Z8F079